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    Kxd1 KxDL motif containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498606, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kxd1provided by RGD
    Official Full Name
    KxDL motif containing 1provided by RGD
    Primary source
    RGD:1562866
    See related
    EnsemblRapid:ENSRNOG00000019971 AllianceGenome:RGD:1562866
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in lysosome localization and vesicle-mediated transport. Predicted to be located in several cellular components, including cytosol; lysosomal membrane; and ribosome. Predicted to be part of BLOC-1 complex and BORC complex. Orthologous to human KXD1 (KxDL motif containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 146.7), Thymus (RPKM 141.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kxd1 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18929316..18950239)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18895343..18916266)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20652863..20666581)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene inositol-3-phosphate synthase 1 Neighboring gene elongation factor for RNA polymerase II Neighboring gene FKBP prolyl isomerase 8 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 Neighboring gene required for excision 1-B domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The BLOS1-interacting protein KXD1 is involved in the biogenesis of lysosome-related organelles. Yang Q, et al. Traffic, 2012 Aug. PMID 22554196, Free PMC Article
    2. BORC, a multisubunit complex that regulates lysosome positioning. Pu J, et al. Dev Cell, 2015 Apr 20. PMID 25898167, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lysosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosome localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of BLOC-1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of BLOC-1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of BORC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BORC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of BORC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kxDL motif-containing protein 1
    Names
    UPF0459 protein C19orf50 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025143.1 → NP_001020314.1  kxDL motif-containing protein 1

      See identical proteins and their annotated locations for NP_001020314.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088216
      UniProtKB/Swiss-Prot
      Q5M853
      UniProtKB/TrEMBL
      A0A8L2QER4, A6KA37
      Conserved Domains (1) summary
      pfam10241
      Location:14 → 93
      KxDL; Uncharacterized conserved protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18929316..18950239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094765.1 → XP_038950693.1  kxDL motif-containing protein 1 isoform X5

      UniProtKB/Swiss-Prot
      Q5M853
      UniProtKB/TrEMBL
      A0A8L2QER4, A6KA37
      Related
      ENSRNOP00000027053.6, ENSRNOT00000027053.6
      Conserved Domains (1) summary
      pfam10241
      Location:14 → 93
      KxDL; Uncharacterized conserved protein

    2. XM_006252922.5 → XP_006252984.1  kxDL motif-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALL5, A0A8L2QER4
      Related
      ENSRNOP00000079541.2, ENSRNOT00000108401.2
      Conserved Domains (1) summary
      pfam10241
      Location:58 → 137
      KxDL; Uncharacterized conserved protein

    3. XM_039094767.2 → XP_038950695.1  kxDL motif-containing protein 1 isoform X8

      Conserved Domains (1) summary
      pfam10241
      Location:58 → 129
      KxDL; Uncharacterized conserved protein

    4. XM_063275641.1 → XP_063131711.1  kxDL motif-containing protein 1 isoform X7

    5. XM_039094764.2 → XP_038950692.1  kxDL motif-containing protein 1 isoform X3

      Conserved Domains (1) summary
      pfam10241
      Location:58 → 129
      KxDL; Uncharacterized conserved protein

    6. XM_063275640.1 → XP_063131710.1  kxDL motif-containing protein 1 isoform X6

    7. XM_006252923.5 → XP_006252985.1  kxDL motif-containing protein 1 isoform X5

      See identical proteins and their annotated locations for XP_006252985.1

      UniProtKB/Swiss-Prot
      Q5M853
      UniProtKB/TrEMBL
      A0A8L2QER4, A6KA37
      Conserved Domains (1) summary
      pfam10241
      Location:14 → 93
      KxDL; Uncharacterized conserved protein

    8. XM_063275639.1 → XP_063131709.1  kxDL motif-containing protein 1 isoform X4

    9. XM_006252924.3 → XP_006252986.1  kxDL motif-containing protein 1 isoform X5

      See identical proteins and their annotated locations for XP_006252986.1

      UniProtKB/Swiss-Prot
      Q5M853
      UniProtKB/TrEMBL
      A0A8L2QER4, A6KA37
      Conserved Domains (1) summary
      pfam10241
      Location:14 → 93
      KxDL; Uncharacterized conserved protein

    10. XM_039094763.2 → XP_038950691.1  kxDL motif-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QER4
      Related
      ENSRNOP00000093549.2, ENSRNOT00000097213.2
      Conserved Domains (1) summary
      pfam10241
      Location:56 → 135
      KxDL; Uncharacterized conserved protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M853.1 GenPept UniProtKB/Swiss-Prot:Q5M853

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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