SSTR2 somatostatin receptor 2 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: SSTR2provided by VGNC
Official Full Name: somatostatin receptor 2provided by VGNC
Primary source: VGNC:VGNC:99086
See related: Ensembl:ENSSSCG00000017249
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Biased expression in kidney (RPKM 2.8), ovary (RPKM 1.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	12	NC_010454.4 (7783401..7789483, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	12	NC_010454.3 (8063456..8069876, complement)

Chromosome 12 - NC_010454.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data demonstrate that urotensin II and urotensin II-related peptide directly activate somatostatin receptors 2 and 5 and thus mimic the effect of somatostatin on its cognate receptors.
Title: Urotensin II and urotensin II-related peptide activate somatostatin receptor subtypes 2 and 5.
is a potent inhibitory receptor displaying a unique set of interrelated dynamic features of agonist-dependent dimerization, dissociation, internalization, and reassociation, a cascade of events that might be critical for receptor function
Title: Porcine somatostatin receptor 2 displays typical pharmacological sst2 features but unique dynamics of homodimerization and internalization.
SRIF can inhibit testosterone secretion through the sst2A receptor; local inhibitory action of SRIF is probably autocrine & might involve testosterone-induced increase of sst2 receptor expression in immature Leydig cells [SST2A]
Title: Expression of somatostatin receptor type-2 (sst2A) in immature porcine Leydig cells and a possible role in the local control of testosterone secretion.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables neuropeptide binding	IEA Inferred from Electronic Annotation more info	PubMed
enables somatostatin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: somatostatin receptor type 2

Names: SRIF-1; SS-2-R; SS2-R; SS2R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011694.1 → NP_001011694.1 somatostatin receptor type 2

See identical proteins and their annotated locations for NP_001011694.1

Status: PROVISIONAL

Source sequence(s)

D21338

UniProtKB/Swiss-Prot

P34994

UniProtKB/TrEMBL

A0A480ZK14, A0A8D0MDT8

Conserved Domains (2) summary

pfam00001
Location:60 → 312

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:51 → 238

7tm_4; Olfactory receptor