CTSD cathepsin D [Sus scrofa (pig)] - Gene

Summary

Official Symbol: CTSDprovided by VGNC
Official Full Name: cathepsin Dprovided by VGNC
Primary source: VGNC:VGNC:112733
See related: Ensembl:ENSSSCG00000040793
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Ubiquitous expression in lung (RPKM 400.1), spleen (RPKM 222.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	2	NC_010444.4 (1188548..1197642, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	Unplaced Scaffold	NW_003541064.1 (1922..8307)

Chromosome 2 - NC_010444.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

g.70G>A polymorphism affects fatness and muscle deposition on SSC2p
Title: The insulin-like growth factor 2 (IGF2) gene intron3-g.3072G>A polymorphism is not the only Sus scrofa chromosome 2p mutation affecting meat production and carcass traits in pigs: evidence from the effects of a cathepsin D (CTSD) gene polymorphism.
Polymorphisms were discovered in several pig breeds, mostly in intron 4 and 5, including missense mutations, synonymous mutations, and intronic subsitutions.
Title: Sequence identification, tissue distribution and polymorphism of the porcine cathepsin D (CTSD) gene.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in lysosome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cathepsin D

NP_001032810.1

EC 3.4.23.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037721.1 → NP_001032810.1 cathepsin D precursor

See identical proteins and their annotated locations for NP_001032810.1

Status: PROVISIONAL

Source sequence(s)

DQ018727

UniProtKB/TrEMBL

A0A8D1QNB0, Q4U1U4

Related

ENSSSCP00000036066.3, ENSSSCT00000052185.3

Conserved Domains (3) summary

cd05490
Location:73 → 406

Cathepsin_D2; Cathepsin_D2, pepsin family of proteinases

pfam00026
Location:80 → 407

Asp; Eukaryotic aspartyl protease

pfam07966
Location:22 → 46

A1_Propeptide; A1 Propeptide