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    Fbxl16 F-box and leucine-rich repeat protein 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 494223, updated on 2-Nov-2024

    Summary

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    Symbol
    Fbxl16provided by RGD
    Full Name
    F-box and leucine-rich repeat protein 16provided by RGD
    Primary source
    RGD:1309127
    See related
    EnsemblRapid:ENSRNOG00000022248 AllianceGenome:RGD:1309127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Scirr1
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm. Orthologous to human FBXL16 (F-box and leucine rich repeat protein 16). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 229.1) and Adrenal (RPKM 11.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxl16 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15333996..15346253)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14829453..14841739)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15176489..15188729)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 78 Neighboring gene adenine nucleotide translocase lysine methyltransferase Neighboring gene meteorin, glial cell differentiation regulator Neighboring gene WD repeat domain 24 Neighboring gene jumonji domain containing 8 Neighboring gene STIP1 homology and U-box containing protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of scirr1, a novel gene up-regulated after spinal cord injury. Liu T, et al. Exp Mol Med, 2007 Jun 30. PMID 17603280
    2. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCIRR1 ise involved in the succeeding injury and/or repair processes of the injured spinal cord
      Title: Identification and characterization of scirr1, a novel gene up-regulated after spinal cord injury.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 16
    Names
    spinal cord injury and regeneration related 1
    spinal cord injury and regeneration-related protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009504.3 → NP_001009504.1  F-box/LRR-repeat protein 16

      See identical proteins and their annotated locations for NP_001009504.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q5MJ12
      UniProtKB/TrEMBL
      A6HD57
      Related
      ENSRNOP00000102449.1, ENSRNOT00000157201.1
      Conserved Domains (2) summary
      cd09293
      Location:201 → 413
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:220 → 243
      LRR_AMN1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15333996..15346253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086539.2 → XP_038942467.1  F-box/LRR-repeat protein 16 isoform X1

      Related
      ENSRNOP00000035846.2, ENSRNOT00000039777.3
      Conserved Domains (2) summary
      cd09293
      Location:201 → 422
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:195 → 219
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. XM_039086540.2 → XP_038942468.1  F-box/LRR-repeat protein 16 isoform X1

      Conserved Domains (2) summary
      cd09293
      Location:201 → 422
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:195 → 219
      LRR_AMN1; leucine-rich repeat [structural motif]

    3. XM_063269580.1 → XP_063125650.1  F-box/LRR-repeat protein 16 isoform X2

      UniProtKB/Swiss-Prot
      Q5MJ12
      UniProtKB/TrEMBL
      A6HD57
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5MJ12.1 GenPept UniProtKB/Swiss-Prot:Q5MJ12

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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