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    TSHR thyroid stimulating hormone receptor [ Felis catus (domestic cat) ]

    Gene ID: 493842, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TSHR
    Official Full Name
    thyroid stimulating hormone receptor
    Primary source
    VGNC:VGNC:66617
    See related
    EnsemblRapid:ENSFCTG00005013310
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Also known as
    TSH-R
    Orthologs
    human mouse all
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    Genomic context

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    See TSHR in Genome Data Viewer
    Location:
    chromosome: B3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) B3 NC_058373.1 (125203157..125367135)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) B3 NC_018728.3 (127702015..127865731)

    Chromosome B3 - NC_058373.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC109500952 Neighboring gene uncharacterized LOC102900788 Neighboring gene centrosomal protein 128 Neighboring gene charged multivesicular body protein 3-like Neighboring gene small nucleolar RNA SNORA79 Neighboring gene uncharacterized LOC109500956 Neighboring gene uncharacterized LOC109500955 Neighboring gene general transcription factor IIA subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of the cat TSH receptor and evidence against an autoimmune etiology of feline hyperthyroidism. Nguyen LQ, et al. Endocrinology, 2002 Feb. PMID 11796491
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables thyroid-stimulating hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thyrotropin receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009288.1 → NP_001009288.1  thyrotropin receptor precursor

      See identical proteins and their annotated locations for NP_001009288.1

      Status: PROVISIONAL

      Source sequence(s)
      AF218264
      UniProtKB/Swiss-Prot
      Q9BGN4
      UniProtKB/TrEMBL
      M3WEF8
      Conserved Domains (4) summary
      sd00033
      Location:78 → 102
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00001
      Location:430 → 677
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam13855
      Location:76 → 138
      LRR_8; Leucine rich repeat
      cl21561
      Location:422 → 629
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058373.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      125203157..125367135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_019831721.2 → XP_019687280.1  thyrotropin receptor isoform X1

      UniProtKB/TrEMBL
      A0A2I2U839, A0A337SC75
      Conserved Domains (3) summary
      sd00033
      Location:78 → 102
      LRR_RI; leucine-rich repeat [structural motif]
      cd15964
      Location:421 → 695
      7tmA_TSH-R; thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors
      cl26222
      Location:65 → 228
      LRR_5; Leucine rich repeats (6 copies)

    2. XM_019831722.3 → XP_019687281.1  thyrotropin receptor isoform X2

      UniProtKB/TrEMBL
      A0A2I2ULI7, M3WEF8
      Related
      ENSFCTP00005026720.1, ENSFCTT00005038216.1
      Conserved Domains (3) summary
      sd00033
      Location:78 → 102
      LRR_RI; leucine-rich repeat [structural motif]
      cd15964
      Location:414 → 688
      7tmA_TSH-R; thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors
      cl26222
      Location:65 → 221
      LRR_5; Leucine rich repeats (6 copies)

    3. XM_019831724.2 → XP_019687283.1  thyrotropin receptor isoform X3

      UniProtKB/TrEMBL
      A0A2I2V0E6, A0A337SC75
      Conserved Domains (4) summary
      sd00033
      Location:55 → 77
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:62 → 113
      LRR_8; Leucine rich repeat
      cd15964
      Location:396 → 670
      7tmA_TSH-R; thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors
      cl26222
      Location:60 → 203
      LRR_5; Leucine rich repeats (6 copies)

    4. XM_019831726.2 → XP_019687285.1  thyrotropin receptor isoform X4

      UniProtKB/TrEMBL
      M3WEF8
      Related
      ENSFCTP00005026561.1, ENSFCTT00005038024.1
      Conserved Domains (3) summary
      sd00033
      Location:55 → 77
      LRR_RI; leucine-rich repeat [structural motif]
      cd15964
      Location:389 → 663
      7tmA_TSH-R; thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors
      cl26222
      Location:60 → 196
      LRR_5; Leucine rich repeats (6 copies)

    5. XM_019831728.2 → XP_019687287.1  thyrotropin receptor isoform X5

      UniProtKB/TrEMBL
      A0A2I2UW04, M3WEF8
      Related
      ENSFCTP00005026634.1, ENSFCTT00005038112.1
      Conserved Domains (2) summary
      sd00033
      Location:54 → 78
      LRR_RI; leucine-rich repeat [structural motif]
      cd15964
      Location:372 → 646
      7tmA_TSH-R; thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors

    6. XM_019831730.2 → XP_019687289.1  thyrotropin receptor isoform X6

      UniProtKB/TrEMBL
      M3WEF8
      Conserved Domains (2) summary
      sd00033
      Location:45 → 75
      LRR_RI; leucine-rich repeat [structural motif]
      cd15964
      Location:319 → 593
      7tmA_TSH-R; thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BGN4.1 GenPept UniProtKB/Swiss-Prot:Q9BGN4

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials