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    IL6 interleukin 6 [ Felis catus (domestic cat) ]

    Gene ID: 493687, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IL6
    Official Full Name
    interleukin 6
    Primary source
    VGNC:VGNC:67781
    See related
    EnsemblRapid:ENSFCTG00005010729
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Orthologs
    human mouse all
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    Genomic context

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    See IL6 in Genome Data Viewer
    Location:
    chromosome: A2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) A2 NC_058369.1 (115008819..115014044)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) A2 NC_018724.3 (116632046..116637410)

    Chromosome A2 - NC_058369.1Genomic Context describing neighboring genes Neighboring gene glutamate-rich protein 2-like Neighboring gene uncharacterized LOC123383982 Neighboring gene uncharacterized LOC109497482 Neighboring gene translocase of outer mitochondrial membrane 7 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic signatures of feline chronic gingivostomatitis are influenced by upregulated IL6. Peralta S, et al. Sci Rep, 2023 Aug 18. PMID 37596310, Free PMC Article
    2. Molecular cloning and characterization of a cDNA encoding feline interleukin-6. Bradley WG, et al. Proc Soc Exp Biol Med, 1993 Dec. PMID 8234373
    3. Molecular cloning of feline interleukin-6 cDNA. Ohashi T, et al. J Vet Med Sci, 1993 Dec. PMID 8117820
    4. Cytokine mRNA expression in lesions in cats with chronic gingivostomatitis. Harley R, et al. Clin Diagn Lab Immunol, 1999 Jul. PMID 10391845, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcriptomic signatures of feline chronic gingivostomatitis are influenced by upregulated IL6.
      Title: Transcriptomic signatures of feline chronic gingivostomatitis are influenced by upregulated IL6.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables interleukin-6 receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T-helper 17 cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-6
    Names
    IL-6
    interleukin 6 (interferon, beta 2)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009211.2 → NP_001009211.2  interleukin-6 precursor

      Status: VALIDATED

      Source sequence(s)
      AF054603, D13227, L16914
      UniProtKB/Swiss-Prot
      P41683
      Conserved Domains (1) summary
      pfam00489
      Location:28 → 207
      IL6; Interleukin-6/G-CSF/MGF family

    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058369.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      115008819..115014044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_019814895.2 → XP_019670454.2  interleukin-6 isoform X1

      UniProtKB/TrEMBL
      M3X721
      Related
      ENSFCTP00005019689.1, ENSFCTT00005030036.1
      Conserved Domains (1) summary
      smart00126
      Location:70 → 223
      IL6; Interleukin-6 homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41683.1 GenPept UniProtKB/Swiss-Prot:P41683

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials