TNFRSF4 TNF receptor superfamily member 4 [Felis catus (domestic cat)] - Gene

Summary

Official Symbol: TNFRSF4
Official Full Name: TNF receptor superfamily member 4
Primary source: VGNC:VGNC:66411
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Felis catus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Also known as: OX40; CD134
Orthologs: human mouse all
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Genomic context

Location:: chromosome: C1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
105	current	F.catus_Fca126_mat1.0 (GCF_018350175.1)	C1	NC_058375.1 (316581..321234, complement)
104	previous assembly	Felis_catus_9.0 (GCF_000181335.3)	C1	NC_018730.3 (313883..321324, complement)

Chromosome C1 - NC_058375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that OrfA acts to markedly reduce cell surface expression of the FIV primary binding receptor, CD134.
Title: OrfA downregulates feline immunodeficiency virus primary receptor CD134 on the host cell surface and is important in viral infection.
Data show that the presence of antibodies to CD134 correlated with lower virus loads and a better overall health status in FIV(+) cats.
Title: Improved health and survival of FIV-infected cats is associated with the presence of autoantibodies to the primary receptor, CD134.
Expression of CD134 and CXCR4 on feline T and B and dendritic cells (and macrophages was examined and the kinetics of feline immunodeficiency virus replication were assessed.
Title: CD134 and CXCR4 expression corresponds to feline immunodeficiency virus infection of lymphocytes, macrophages and dendritic cells.
These findings provide direct evidence for a sequential interaction of FIV Env with CD134 and CXCR4.
Title: Sequential CD134-CXCR4 interactions in feline immunodeficiency virus (FIV): soluble CD134 activates FIV Env for CXCR4-dependent entry and reveals a cryptic neutralization epitope.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables tumor necrosis factor receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 4

Names: tumor necrosis factor receptor superfamily, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009200.1 → NP_001009200.1 tumor necrosis factor receptor superfamily member 4 precursor

See identical proteins and their annotated locations for NP_001009200.1

Status: PROVISIONAL

Source sequence(s)

AY738589

UniProtKB/TrEMBL

Q75SV8

Conserved Domains (1) summary

cd13406
Location:30 → 171

TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40