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    SERCA Sarco/endoplasmic reticulum Ca(2+)-ATPase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49297, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SERCAprovided by FlyBase
    Official Full Name
    Sarco/endoplasmic reticulum Ca(2+)-ATPaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263006
    Locus tag
    Dmel_CG3725
    See related
    AllianceGenome:FB:FBgn0263006
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    17136664; A4UZU0_DROME; ATC1_DROME; Ca-ATPase; Ca-p; Ca-P60; Ca-P60A; CA-P60A; CaP60A; Ca[2+]ATPase; Ca[2+]P60A; CG3725; Dmel\CG3725; dserca; dSERCA; kum; Kum; l(2)k08308ab; l(2)k09025; l(2)SH0211; serca; Serca; SERCA2; Serca2a
    Summary
    Enables P-type calcium transporter activity. Involved in several processes, including calcium ion transport from cytosol to endoplasmic reticulum; intestinal stem cell homeostasis; and stabilization of membrane potential. Located in sarcoplasmic reticulum. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including adult central nervous system; embryonic/larval midgut primordium; germline cell; gut section; and muscle cell. Used to study Brody myopathy and heart disease. Human ortholog(s) of this gene implicated in Brody myopathy; acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1); ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2); and ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

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    See SERCA in Genome Data Viewer
    Location:
    60A11-60A12; 2-105 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23925077..23935884, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19812600..19823407, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45926 Neighboring gene antisense RNA:CR44806 Neighboring gene Nucleosome assembly protein 1 Neighboring gene kazachoc Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Transaldolase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and chromosomal localization of a sarco/endoplasmic reticulum-type Ca2(+)-ATPase of Drosophila melanogaster. Magyar A, et al. Biochem Biophys Res Commun, 1990 Dec 31. PMID 2148477
    2. SERCA is critical to control the Bowditch effect in the heart. Balcazar D, et al. Sci Rep, 2018 Aug 20. PMID 30127403, Free PMC Article
    3. Identification of a pathogenic mutation in ATP2A1 via in silico analysis of exome data for cryptic aberrant splice sites. Bruels CC, et al. Mol Genet Genomic Med, 2019 Mar. PMID 30688039, Free PMC Article
    4. Different mechanisms of Ca2+ regulation that influence synaptic transmission: comparison between crayfish and Drosophila neuromuscular junctions. Desai-Shah M, et al. Synapse, 2009 Dec. PMID 19650116
    5. Probing the Fractal Pattern of Heartbeats in Drosophila Pupae by Visible Optical Recording System. Lin C, et al. Sci Rep, 2016 Aug 18. PMID 27535299, Free PMC Article

    See all (213) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expanded polyQ aggregates interact with sarco-endoplasmic reticulum calcium ATPase and Drosophila inhibitor of apoptosis protein1 to regulate polyQ mediated neurodegeneration in Drosophila.
      Title: Expanded polyQ aggregates interact with sarco-endoplasmic reticulum calcium ATPase and Drosophila inhibitor of apoptosis protein1 to regulate polyQ mediated neurodegeneration in Drosophila.
    2. SERCA is required for border cell migration by regulating cytoplasmic Ca2+ homeostasis independent of unfolded protein response.
      Title: SERCA regulates collective cell migration by maintaining cytoplasmic Ca(2+) homeostasis.
    3. Mutations in SERCA disrupt Wingless signaling by sequestering Armadillo/beta-catenin away from the signaling pool. Elimination of SERCA function results in apoptosis.
      Title: Reduced SERCA Function Preferentially Affects Wnt Signaling by Retaining E-Cadherin in the Endoplasmic Reticulum.
    4. Disruption of CaP60A function in Drosophila leads to cardiac dysfunction.
      Title: Disruption of sarcoendoplasmic reticulum calcium ATPase function in Drosophila leads to cardiac dysfunction.
    5. A dominant mutation altering SERCA confers temperature-sensitive uncoordination in a gain-of-function manner.
      Title: Ionic leakage underlies a gain-of-function effect of dominant disease mutations affecting diverse P-type ATPases.
    6. Heart beat frequency is strikingly reduced in mutant animals following dSERCA inactivation
      Title: Conditional mutations in SERCA, the Sarco-endoplasmic reticulum Ca2+-ATPase, alter heart rate and rhythmicity in Drosophila.
    7. Analysis of conditional paralytic mutants in SERCA reveals novel mechanisms for regulating membrane excitability.
      Title: Analysis of conditional paralytic mutants in Drosophila sarco-endoplasmic reticulum calcium ATPase reveals novel mechanisms for regulating membrane excitability.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type calcium transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adaptive thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport from cytosol to endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transport from cytosol to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flight behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intestinal stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of sequestering of calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stabilization of membrane potential IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sarco/endoplasmic reticulum Ca(2+)-ATPase
    Names
    CG3725-PA
    CG3725-PB
    CG3725-PC
    CG3725-PD
    CG3725-PE
    CG3725-PF
    CG3725-PG
    CG3725-PH
    CG3725-PI
    Ca[2+] ATPase
    SERCA-PA
    SERCA-PB
    SERCA-PC
    SERCA-PD
    SERCA-PE
    SERCA-PF
    SERCA-PG
    SERCA-PH
    SERCA-PI
    calcium ATPase
    calcium ATPase at 60A
    endoplasmic reticulum-specific calcium-transporting ATPase
    kumbhakarna
    lethal (2) SH0211
    organellar-type Ca-ATPase
    sarco endoplasmic reticulum calcium-ATPase
    sarco/endoplasmic reticulum-type Ca-2+-ATPase
    sarcoplasmic endoplasmic reticulum calcium ATPase type 2
    serca
    NP_001286796.1
    NP_476832.1
    NP_726381.1
    NP_726382.1
    NP_726383.1
    NP_726384.1
    NP_726385.1
    NP_726386.1
    NP_726387.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23925077..23935884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299867.1 → NP_001286796.1  Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286796.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGB7
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:5 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 527
      Cation_ATPase; Cation transport ATPase (P-type)

    2. NM_057484.3 → NP_476832.1  Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476832.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P22700
      Related
      FBpp0072124
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:5 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 527
      Cation_ATPase; Cation transport ATPase (P-type)

    3. NM_166639.2 → NP_726387.1  Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726387.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZU0, P22700, Q2MGN2, Q95TX1, Q9W1G2, Q9W1G3
      UniProtKB/TrEMBL
      E8NHA8
      Related
      FBpp0072125
      Conserved Domains (1) summary
      cd02083
      Location:5 → 989
      P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3

    4. NM_166638.2 → NP_726386.1  Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726386.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZU0, P22700, Q2MGN2, Q95TX1, Q9W1G2, Q9W1G3
      UniProtKB/TrEMBL
      E8NHA8
      Related
      FBpp0072120
      Conserved Domains (1) summary
      cd02083
      Location:5 → 989
      P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3

    5. NM_166636.2 → NP_726384.1  Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726384.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZU0, P22700, Q2MGN2, Q95TX1, Q9W1G2, Q9W1G3
      UniProtKB/TrEMBL
      E8NHA8
      Related
      FBpp0072121
      Conserved Domains (1) summary
      cd02083
      Location:5 → 989
      P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3

    6. NM_166633.2 → NP_726381.1  Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726381.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZU0, P22700, Q2MGN2, Q95TX1, Q9W1G2, Q9W1G3
      UniProtKB/TrEMBL
      E8NHA8
      Related
      FBpp0072122
      Conserved Domains (1) summary
      cd02083
      Location:5 → 989
      P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3

    7. NM_166635.2 → NP_726383.1  Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726383.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZU0, P22700, Q2MGN2, Q95TX1, Q9W1G2, Q9W1G3
      UniProtKB/TrEMBL
      E8NHA8
      Related
      FBpp0072123
      Conserved Domains (1) summary
      cd02083
      Location:5 → 989
      P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3

    8. NM_166634.2 → NP_726382.1  Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726382.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZU0, P22700, Q2MGN2, Q95TX1, Q9W1G2, Q9W1G3
      UniProtKB/TrEMBL
      E8NHA8
      Related
      FBpp0072126
      Conserved Domains (1) summary
      cd02083
      Location:5 → 989
      P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3

    9. NM_166637.2 → NP_726385.1  Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726385.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZU0, P22700, Q2MGN2, Q95TX1, Q9W1G2, Q9W1G3
      UniProtKB/TrEMBL
      E8NHA8
      Related
      FBpp0072127
      Conserved Domains (1) summary
      cd02083
      Location:5 → 989
      P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGB7 A0A0B4LGB7
    P22700.2 P22700
    Q95SB1 Q95SB1

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