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    GRIN2A glutamate ionotropic receptor NMDA type subunit 2A [ Canis lupus familiaris (dog) ]

    Gene ID: 490012, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GRIN2Aprovided by VGNC
    Official Full Name
    glutamate ionotropic receptor NMDA type subunit 2Aprovided by VGNC
    Primary source
    VGNC:VGNC:41492
    See related
    Ensembl:ENSCAFG00845013576
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See GRIN2A in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (32315346..32865008)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (33514238..34067205)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (32426676..32972580)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (32128354..32680283)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (32000797..32549532)

    Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene tektin 5 Neighboring gene activating transcription factor 7 interacting protein 2 Neighboring gene epithelial membrane protein 2 Neighboring gene uncharacterized LOC111096303 Neighboring gene HUWE1 associated protein modifying stress responses Neighboring gene ubiquitin specific peptidase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NMDA glutamate receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NMDA selective glutamate receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate receptor ionotropic, NMDA 2A
    Names
    glutamate receptor ionotropic N-methyl D-aspartate 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051810.1 Reference ROS_Cfam_1.0

      Range
      32315346..32865008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038669185.1 → XP_038525113.1  glutamate receptor ionotropic, NMDA 2A

      UniProtKB/TrEMBL
      A0A8C0LKI2, A0A8C0N398, A0A8I3NRD6
      Conserved Domains (3) summary
      cd13718
      Location:403 → 802
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06378
      Location:32 → 387
      PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      pfam10565
      Location:839 → 1464
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

    2. XM_038669186.1 → XP_038525114.1  glutamate receptor ionotropic, NMDA 2A

      UniProtKB/TrEMBL
      A0A8C0LKI2, A0A8C0N398, A0A8I3NRD6
      Related
      ENSCAFP00845019017.1, ENSCAFT00845024210.1
      Conserved Domains (3) summary
      cd13718
      Location:403 → 802
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06378
      Location:32 → 387
      PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      pfam10565
      Location:839 → 1464
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

    RNA

    1. XR_005428614.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049266.1 Alternate UMICH_Zoey_3.1

      Range
      32128354..32680283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038479172.1 → XP_038335100.1  glutamate receptor ionotropic, NMDA 2A

      Conserved Domains (3) summary
      cd13718
      Location:403 → 802
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06378
      Location:32 → 387
      PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      pfam10565
      Location:839 → 1464
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

    2. XM_038479173.1 → XP_038335101.1  glutamate receptor ionotropic, NMDA 2A

      Conserved Domains (3) summary
      cd13718
      Location:403 → 802
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06378
      Location:32 → 387
      PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      pfam10565
      Location:839 → 1464
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

    RNA

    1. XR_005327007.1 RNA Sequence

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

      Range
      32000797..32549532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038604499.1 → XP_038460427.1  glutamate receptor ionotropic, NMDA 2A

      Conserved Domains (3) summary
      cd13718
      Location:403 → 802
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06378
      Location:32 → 387
      PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      pfam10565
      Location:839 → 1464
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

    2. XM_038604500.1 → XP_038460428.1  glutamate receptor ionotropic, NMDA 2A

      Conserved Domains (3) summary
      cd13718
      Location:403 → 802
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06378
      Location:32 → 387
      PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      pfam10565
      Location:839 → 1464
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

    RNA

    1. XR_005395448.1 RNA Sequence

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

      Range
      32426676..32972580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038540398.1 → XP_038396326.1  glutamate receptor ionotropic, NMDA 2A

      UniProtKB/TrEMBL
      A0A8C0LKI2, A0A8C0N398, A0A8I3NRD6
      Conserved Domains (3) summary
      cd13718
      Location:403 → 802
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06378
      Location:32 → 387
      PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      pfam10565
      Location:839 → 1464
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

    2. XM_038540400.1 → XP_038396328.1  glutamate receptor ionotropic, NMDA 2A

      UniProtKB/TrEMBL
      A0A8C0LKI2, A0A8C0N398, A0A8I3NRD6
      Conserved Domains (3) summary
      cd13718
      Location:403 → 802
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06378
      Location:32 → 387
      PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      pfam10565
      Location:839 → 1464
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

    RNA

    1. XR_005360918.1 RNA Sequence

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      33514238..34067205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005621556.4 → XP_005621613.1  glutamate receptor ionotropic, NMDA 2A

      See identical proteins and their annotated locations for XP_005621613.1

      UniProtKB/TrEMBL
      A0A8C0LKI2, A0A8C0N398, A0A8I3NRD6
      Conserved Domains (3) summary
      cd13718
      Location:403 → 802
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06378
      Location:32 → 387
      PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      pfam10565
      Location:839 → 1464
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

    2. XM_547132.7 → XP_547132.2  glutamate receptor ionotropic, NMDA 2A

      See identical proteins and their annotated locations for XP_547132.2

      UniProtKB/TrEMBL
      A0A8C0LKI2, A0A8C0N398, A0A8I3NRD6
      Conserved Domains (3) summary
      cd13718
      Location:403 → 802
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06378
      Location:32 → 387
      PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      pfam10565
      Location:839 → 1464
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

    RNA

    1. XR_002627602.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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