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    LRRK2 leucine rich repeat kinase 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 486608, updated on 17-Aug-2024

    Summary

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    Official Symbol
    LRRK2provided by VGNC
    Official Full Name
    leucine rich repeat kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:42823
    See related
    Ensembl:ENSCAFG00845030702
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See LRRK2 in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (13454479..13594189, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (33032944..33171543)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (33159660..33299460)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (13240908..13387064, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (13302124..13442060, complement)

    Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene mucin 19, oligomeric Neighboring gene uncharacterized LOC119866308 Neighboring gene uncharacterized LOC111092839 Neighboring gene elongation factor 1-gamma-like Neighboring gene solute carrier family 2 member 13 Neighboring gene regulator of DNA class I crossover intermediates 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat serine/threonine-protein kinase 2
    XP_038294443.1
    XP_038369123.1
    XP_038433235.1
    XP_038496906.1
    XP_543734.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051831.1 Reference ROS_Cfam_1.0

      Range
      13454479..13594189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038438515.1 → XP_038294443.1  leucine-rich repeat serine/threonine-protein kinase 2

      UniProtKB/TrEMBL
      A0A8C0L640, A0A8C0L674, A0A8C0P161, A0A8I3QYS6
      Related
      ENSCAFP00845042845.1, ENSCAFT00845054508.1
      Conserved Domains (5) summary
      COG4886
      Location:1012 → 1306
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd14068
      Location:1884 → 2135
      STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
      sd00033
      Location:1013 → 1036
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16095
      Location:1527 → 1740
      COR; C-terminal of Roc, COR, domain
      cl38936
      Location:1334 → 1507
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049287.1 Alternate UMICH_Zoey_3.1

      Range
      13240908..13387064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038513195.1 → XP_038369123.1  leucine-rich repeat serine/threonine-protein kinase 2

      Conserved Domains (5) summary
      COG4886
      Location:1012 → 1306
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd14068
      Location:1884 → 2135
      STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
      sd00033
      Location:1013 → 1036
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16095
      Location:1527 → 1740
      COR; C-terminal of Roc, COR, domain
      cl38936
      Location:1334 → 1507
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

      Range
      13302124..13442060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038640978.1 → XP_038496906.1  leucine-rich repeat serine/threonine-protein kinase 2

      Conserved Domains (5) summary
      COG4886
      Location:1012 → 1306
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd14068
      Location:1884 → 2135
      STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
      sd00033
      Location:1013 → 1036
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16095
      Location:1527 → 1740
      COR; C-terminal of Roc, COR, domain
      cl38936
      Location:1334 → 1507
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

      Range
      33159660..33299460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038577307.1 → XP_038433235.1  leucine-rich repeat serine/threonine-protein kinase 2

      UniProtKB/TrEMBL
      A0A8C0L640, A0A8C0L674, A0A8C0P161, A0A8I3QYS6
      Conserved Domains (5) summary
      COG4886
      Location:1012 → 1306
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd14068
      Location:1884 → 2135
      STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
      sd00033
      Location:1013 → 1036
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16095
      Location:1527 → 1740
      COR; C-terminal of Roc, COR, domain
      cl38936
      Location:1334 → 1507
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      33032944..33171543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_543734.7 → XP_543734.3  leucine-rich repeat serine/threonine-protein kinase 2

      UniProtKB/TrEMBL
      A0A8C0L640, A0A8C0L674, A0A8C0P161, A0A8I3QYS6
      Conserved Domains (5) summary
      COG4886
      Location:1012 → 1306
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd14068
      Location:1884 → 2135
      STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
      sd00033
      Location:1013 → 1036
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16095
      Location:1527 → 1740
      COR; C-terminal of Roc, COR, domain
      cl38936
      Location:1334 → 1507
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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