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    GDF5 growth differentiation factor 5 [ Canis lupus familiaris (dog) ]

    Gene ID: 485850, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GDF5provided by VGNC
    Official Full Name
    growth differentiation factor 5provided by VGNC
    Primary source
    VGNC:VGNC:41163
    See related
    Ensembl:ENSCAFG00845019680
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See GDF5 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (25088106..25092591, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (24041515..24046000, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (24908900..24913385, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (24374851..24379335, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (24469869..24474354, complement)

    Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 6 Neighboring gene family with sequence similarity 83 member C Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 1 Neighboring gene 60S ribosomal protein L22-like Neighboring gene centrosomal protein 250 Neighboring gene CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    growth/differentiation factor 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051828.1 Reference ROS_Cfam_1.0

      Range
      25088106..25092591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038433621.1 → XP_038289549.1  growth/differentiation factor 5

      UniProtKB/TrEMBL
      A0A8C0JY79, A0A8C0P3X1, A0A8I3PHL7
      Related
      ENSCAFP00845027166.1, ENSCAFT00845034686.1
      Conserved Domains (3) summary
      PHA03247
      Location:30 → 173
      PHA03247; large tegument protein UL36; Provisional
      cd19399
      Location:397 → 499
      TGF_beta_GDF5; transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5) and similar proteins
      cl02928
      Location:152 → 342
      TGFb_propeptide; TGF-beta propeptide

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049284.1 Alternate UMICH_Zoey_3.1

      Range
      24374851..24379335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038508799.1 → XP_038364727.1  growth/differentiation factor 5

      Conserved Domains (3) summary
      PHA03247
      Location:30 → 173
      PHA03247; large tegument protein UL36; Provisional
      cd19399
      Location:397 → 499
      TGF_beta_GDF5; transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5) and similar proteins
      cl02928
      Location:152 → 342
      TGFb_propeptide; TGF-beta propeptide

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

      Range
      24469869..24474354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038636362.1 → XP_038492290.1  growth/differentiation factor 5

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

      Range
      24908900..24913385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038572109.1 → XP_038428037.1  growth/differentiation factor 5

      UniProtKB/TrEMBL
      A0A8C0JY79, A0A8C0P3X1, A0A8I3PHL7
      Conserved Domains (3) summary
      PHA03247
      Location:30 → 173
      PHA03247; large tegument protein UL36; Provisional
      cd19399
      Location:397 → 499
      TGF_beta_GDF5; transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5) and similar proteins
      cl02928
      Location:152 → 342
      TGFb_propeptide; TGF-beta propeptide

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      24041515..24046000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_542974.7 → XP_542974.1  growth/differentiation factor 5

      UniProtKB/TrEMBL
      A0A8C0JY79, A0A8C0P3X1, A0A8I3PHL7
      Conserved Domains (3) summary
      PHA03247
      Location:30 → 173
      PHA03247; large tegument protein UL36; Provisional
      cd19399
      Location:397 → 499
      TGF_beta_GDF5; transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5) and similar proteins
      cl02928
      Location:152 → 342
      TGFb_propeptide; TGF-beta propeptide
    Nucleotide Protein
    Heading Accession and Version

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