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    MAP3K10 mitogen-activated protein kinase kinase kinase 10 [ Canis lupus familiaris (dog) ]

    Gene ID: 484504, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MAP3K10provided by VGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 10provided by VGNC
    Primary source
    VGNC:VGNC:53748
    See related
    Ensembl:ENSCAFG00845004014
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See MAP3K10 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (114020015..114037107, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (112823096..112840182, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (114205343..114222433, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (113578951..113596038, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (113211471..113228553, complement)

    Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene AKT serine/threonine kinase 2 Neighboring gene cyclin P Neighboring gene tetratricopeptide repeat domain 9B Neighboring gene uncharacterized LOC119868512 Neighboring gene vomeronasal 1 receptor canFamV1R558

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables JUN kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10; mitogen-activated protein kinase kinase kinase 10
    XP_038305882.1
    XP_038305959.1
    XP_038324059.1
    XP_038324060.1
    XP_038384804.1
    XP_038384805.1
    XP_038449074.1
    XP_038512897.1
    XP_038512898.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051805.1 Reference ROS_Cfam_1.0

      Range
      114020015..114037107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038656970.1 → XP_038512898.1  mitogen-activated protein kinase kinase kinase 10 isoform X2

      UniProtKB/TrEMBL
      A0A8C0R1L7, A0A8C0YWF9, A0A8I3RTA1
      Related
      ENSCAFP00845005748.1, ENSCAFT00845007221.1
      Conserved Domains (2) summary
      cd12059
      Location:20 → 76
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14148
      Location:103 → 360
      STKc_MLK2; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2

    2. XM_038656969.1 → XP_038512897.1  mitogen-activated protein kinase kinase kinase 10 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KPQ6, A0A8C0LZ62, A0A8C0R1L7, A0A8I3MLU5
      Related
      ENSCAFP00845005757.1, ENSCAFT00845007237.1
      Conserved Domains (2) summary
      cd12059
      Location:20 → 76
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cl21453
      Location:103 → 360
      PKc_like; Protein Kinases, catalytic domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049261.1 Alternate UMICH_Zoey_3.1

      Range
      113578951..113596038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038468132.1 → XP_038324060.1  mitogen-activated protein kinase kinase kinase 10 isoform X2

      Conserved Domains (2) summary
      cd12059
      Location:20 → 76
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14148
      Location:103 → 360
      STKc_MLK2; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2

    2. XM_038468131.1 → XP_038324059.1  mitogen-activated protein kinase kinase kinase 10 isoform X1

      Conserved Domains (2) summary
      cd12059
      Location:20 → 76
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cl21453
      Location:103 → 360
      PKc_like; Protein Kinases, catalytic domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

      Range
      113211471..113228553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038593146.1 → XP_038449074.1  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 isoform X1

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

      Range
      114205343..114222433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038528877.1 → XP_038384805.1  mitogen-activated protein kinase kinase kinase 10 isoform X2

      UniProtKB/TrEMBL
      A0A8C0R1L7, A0A8C0YWF9, A0A8I3RTA1
      Conserved Domains (2) summary
      cd12059
      Location:20 → 76
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14148
      Location:103 → 360
      STKc_MLK2; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2

    2. XM_038528876.1 → XP_038384804.1  mitogen-activated protein kinase kinase kinase 10 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KPQ6, A0A8C0LZ62, A0A8C0R1L7, A0A8I3MLU5
      Conserved Domains (2) summary
      cd12059
      Location:20 → 76
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cl21453
      Location:103 → 360
      PKc_like; Protein Kinases, catalytic domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      112823096..112840182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038450031.1 → XP_038305959.1  mitogen-activated protein kinase kinase kinase 10 isoform X2

      UniProtKB/TrEMBL
      A0A8C0R1L7, A0A8C0YWF9, A0A8I3RTA1
      Conserved Domains (2) summary
      cd12059
      Location:20 → 76
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14148
      Location:103 → 360
      STKc_MLK2; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2

    2. XM_038449954.1 → XP_038305882.1  mitogen-activated protein kinase kinase kinase 10 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KPQ6, A0A8C0LZ62, A0A8C0R1L7, A0A8I3MLU5
      Conserved Domains (2) summary
      cd12059
      Location:20 → 76
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cl21453
      Location:103 → 360
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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