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    PLP1 proteolipid protein 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 481002, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PLP1provided by VGNC
    Official Full Name
    proteolipid protein 1provided by VGNC
    Primary source
    VGNC:VGNC:44704
    See related
    Ensembl:ENSCAFG00845023800
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    PLP
    Orthologs
    human mouse all
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    Genomic context

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    See PLP1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (78808649..78825317)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (63420093..63434914)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (77741107..77755923)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (76287255..76302076)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (77974000..77988806)

    Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene mortality factor 4 like 2 Neighboring gene glycine receptor alpha 4 Neighboring gene RAB9B, member RAS oncogene family Neighboring gene late histone H2B.L4-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A point mutation in the proteolipid protein gene of the 'shaking pup' interrupts oligodendrocyte development. Nadon NL, et al. Development, 1990 Oct. PMID 1723945
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables structural constituent of myelin sheath IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in central nervous system myelination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in myelin sheath IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myelin proteolipid protein
    Names
    lipophilin
    proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013834.2 → NP_001013856.1  myelin proteolipid protein

      See identical proteins and their annotated locations for NP_001013856.1

      Status: PROVISIONAL

      Source sequence(s)
      X55317
      UniProtKB/Swiss-Prot
      P23294
      UniProtKB/TrEMBL
      A0A8C0JZG8
      Related
      ENSCAFP00845032966.1, ENSCAFT00845042032.1
      Conserved Domains (1) summary
      pfam01275
      Location:5 → 273
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051843.1 Reference ROS_Cfam_1.0

      Range
      78808649..78825317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038448838.1 → XP_038304766.1  myelin proteolipid protein isoform X1

      UniProtKB/TrEMBL
      A0A8C0JZG8
      Conserved Domains (1) summary
      pfam01275
      Location:5 → 238
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049299.1 Alternate UMICH_Zoey_3.1

      Range
      76287255..76302076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

      Range
      77974000..77988806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

      Range
      77741107..77755923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      63420093..63434914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23294.2 GenPept UniProtKB/Swiss-Prot:P23294

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials