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    CXCR2 C-X-C motif chemokine receptor 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 478905, updated on 5-Mar-2024

    Summary

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    Gene symbol
    CXCR2
    Gene description
    C-X-C motif chemokine receptor 2
    See related
    Ensembl:ENSCAFG00845026443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    IL8RB
    Orthologs
    human mouse all
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    Genomic context

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    See CXCR2 in Genome Data Viewer
    Location:
    chromosome: 37
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 37 NC_051841.1 (24847511..24862398)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 37 NC_006619.4 (25659341..25664768)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 37 NC_049258.1 (24714358..24719785)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 37 NC_049297.1 (24760631..24766058)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 37 NC_049778.1 (24694995..24700420)

    Chromosome 37 - NC_051841.1Genomic Context describing neighboring genes Neighboring gene tensin 1 Neighboring gene uncharacterized LOC111094445 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene chemokine (C-X-C motif) receptor 1 Neighboring gene actin related protein 2/3 complex subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interleukin-8 expression associated with canine mammary tumors. Zuccari DA, et al. Genet Mol Res, 2011. PMID 21863548
    2. The isolation and sequence of canine interleukin-8 receptor. Chang YF, et al. DNA Seq, 1999. PMID 10647821
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interleukin-8 expression associated with canine mammary tumors
      Title: Interleukin-8 expression associated with canine mammary tumors.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables C-X-C chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables interleukin-8 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-X-C chemokine receptor type 2
    Names
    GRO/MGSA receptor
    high affinity interleukin-8 receptor B
    interleukin 8 receptor, beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003151.2 → NP_001003151.2  C-X-C chemokine receptor type 2

      Status: VALIDATED

      Source sequence(s)
      JAAUVH010000368
      UniProtKB/Swiss-Prot
      O97571
      UniProtKB/TrEMBL
      A0A8C0TK08, A0A8I3PZU6
      Related
      ENSCAFP00845036602.1, ENSCAFT00845046624.1
      Conserved Domains (1) summary
      cd15178
      Location:59 → 323
      7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051841.1 Reference ROS_Cfam_1.0

      Range
      24847511..24862398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038447292.1 → XP_038303220.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      O97571
      UniProtKB/TrEMBL
      A0A8C0TK08, A0A8I3PZU6
      Conserved Domains (1) summary
      cd15178
      Location:59 → 323
      7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_038447294.1 → XP_038303222.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      O97571
      UniProtKB/TrEMBL
      A0A8C0TK08, A0A8I3PZU6
      Conserved Domains (1) summary
      cd15178
      Location:59 → 323
      7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_038447293.1 → XP_038303221.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      O97571
      UniProtKB/TrEMBL
      A0A8C0TK08, A0A8I3PZU6
      Conserved Domains (1) summary
      cd15178
      Location:59 → 323
      7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_038447291.1 → XP_038303219.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      O97571
      UniProtKB/TrEMBL
      A0A8C0TK08, A0A8I3PZU6
      Conserved Domains (1) summary
      cd15178
      Location:59 → 323
      7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049297.1 Alternate UMICH_Zoey_3.1

      Range
      24760631..24766058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049778.1 Alternate UNSW_CanFamBas_1.0

      Range
      24694995..24700420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049258.1 Alternate UU_Cfam_GSD_1.0

      Range
      24714358..24719785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006619.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      25659341..25664768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97571.1 GenPept UniProtKB/Swiss-Prot:O97571

    Gene LinkOut

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