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    CKM creatine kinase, M-type [ Canis lupus familiaris (dog) ]

    Gene ID: 476435, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CKMprovided by VGNC
    Official Full Name
    creatine kinase, M-typeprovided by VGNC
    Primary source
    VGNC:VGNC:39291
    See related
    Ensembl:ENSCAFG00845005622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    M-CK; CPK-M
    Orthologs
    human mouse all
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    Genomic context

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    See CKM in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (110741228..110750012)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (109692858..109701637)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (110920541..110929325)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (110416843..110425622)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (110050951..110059969)

    Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene V-type proton ATPase subunit G 1-like Neighboring gene ERCC excision repair 2, TFIIH core complex helicase subunit Neighboring gene kinesin light chain 3 Neighboring gene microtubule affinity regulating kinase 4 Neighboring gene exocyst complex component 3 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Faster O₂ uptake kinetics in canine skeletal muscle in situ after acute creatine kinase inhibition. Grassi B, et al. J Physiol, 2011 Jan 1. PMID 21059760, Free PMC Article
    2. Characterization of MB creatine kinase isoform conversion in vitro and in vivo in dogs. Billadello JJ, et al. J Clin Invest, 1989 May. PMID 2496146, Free PMC Article
    3. Complete nucleotide sequence of dog heart creatine kinase mRNA: conservation of amino acid sequence within and among species. Roman D, et al. Proc Natl Acad Sci U S A, 1985 Dec. PMID 3866230, Free PMC Article
    4. HSC-2DPAGE and the two-dimensional gel electrophoresis database of dog heart proteins. Dunn MJ, et al. Electrophoresis, 1997 Dec. PMID 9504812

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of skeletal muscle creatine kinase increases oxygen uptake kinetics.
      Title: Faster O₂ uptake kinetics in canine skeletal muscle in situ after acute creatine kinase inhibition.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables creatine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphocreatine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    creatine kinase M-type
    Names
    Creatine kinase M chain
    creatine phosphokinase M-type
    NP_001300705.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313776.1 → NP_001300705.1  creatine kinase M-type

      Status: VALIDATED

      Source sequence(s)
      JAAUVH010000354
      UniProtKB/Swiss-Prot
      P05123
      UniProtKB/TrEMBL
      A0A8C0KGJ5, A0A8P0SVC9
      Related
      ENSCAFP00845007817.1, ENSCAFT00845010014.1
      Conserved Domains (1) summary
      cd00716
      Location:16 → 373
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051805.1 Reference ROS_Cfam_1.0

      Range
      110741228..110750012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049261.1 Alternate UMICH_Zoey_3.1

      Range
      110416843..110425622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

      Range
      110050951..110059969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

      Range
      110920541..110929325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      109692858..109701637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05123.3 GenPept UniProtKB/Swiss-Prot:P05123

    Gene LinkOut

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