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    BRAF B-Raf proto-oncogene, serine/threonine kinase [ Canis lupus familiaris (dog) ]

    Gene ID: 475526, updated on 17-Aug-2024

    Summary

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    Official Symbol
    BRAFprovided by VGNC
    Official Full Name
    B-Raf proto-oncogene, serine/threonine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:38514
    See related
    Ensembl:ENSCAFG00845031038
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See BRAF in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (8065738..8237942)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (8989501..9160850)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (7929505..8101841)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (8017140..8188930)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (7861588..8033660)

    Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111090230 Neighboring gene uncharacterized LOC111090231 Neighboring gene mitochondrial ribosomal protein S33 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC119877087 Neighboring gene uncharacterized LOC111090232 Neighboring gene uncharacterized LOC111090233 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene aarF domain containing kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BRAF(V595E) Mutation Associates CCL17 Expression and Regulatory T Cell Recruitment in Urothelial Carcinoma of Dogs. Maeda S, et al. Vet Pathol, 2021 Sep. PMID 33205710
    2. Identifying the ErbB/MAPK Signaling Cascade as a Therapeutic Target in Canine Bladder Cancer. Cronise KE, et al. Mol Pharmacol, 2019 Jul. PMID 31048548
    3. [Diagnostic value of the BRAF variant V595E in urine samples, smears and biopsies from canine transitional cell carcinoma]. Aupperle-Lellbach H, et al. Tierarztl Prax Ausg K Kleintiere Heimtiere, 2018 Oct. PMID 30541168
    4. BRAF Mutations in Canine Cancers. Mochizuki H, et al. PLoS One, 2015. PMID 26053201, Free PMC Article
    5. Exon 15 BRAF mutations are uncommon in canine oral malignant melanomas. Shelly S, et al. Mamm Genome, 2005 Mar. PMID 15834638

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR Mutation Hot Spots in Canine Intestinal Adenocarcinoma.
      Title: EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR Mutation Hot Spots in Canine Intestinal Adenocarcinoma.
    2. BRAF(V595E) Mutation Associates CCL17 Expression and Regulatory T Cell Recruitment in Urothelial Carcinoma of Dogs.
      Title: BRAF(V595E) Mutation Associates CCL17 Expression and Regulatory T Cell Recruitment in Urothelial Carcinoma of Dogs.
    3. Aberrant expression of the COX2/PGE2 axis is induced by activation of the RAF/MEK/ERK pathway in BRAF(V595E) canine urothelial carcinoma.
      Title: Aberrant expression of the COX2/PGE(2) axis is induced by activation of the RAF/MEK/ERK pathway in BRAF(V595E) canine urothelial carcinoma.
    4. Studied use of B-Raf proto-oncogene serine/threonine kinase (BRAF) mutational analysis as a tumor marker in canine transitional cell carcinoma.
      Title: [Diagnostic value of the BRAF variant V595E in urine samples, smears and biopsies from canine transitional cell carcinoma].
    5. a single nucleotide T to A transversion at nucleotide 1349 of BRAF occurred in 64 primary tumors of dogs.
      Title: BRAF Mutations in Canine Cancers.
    6. BRAF alternative splicing is differentially regulated in mammals. Exon 9b is present in vertebrates but exon 8b is present only in eutherians.
      Title: B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse.
    7. canine oral malignant melanomas do not possess codon 599 BRAF mutations commonly identified in human cutaneous melanomas. This supports the notion that melanomas arising from non-sun-exposed sites exhibit distinct mechanisms of molecular transformation.
      Title: Exon 15 BRAF mutations are uncommon in canine oral malignant melanomas.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase B-raf
    Names
    B-raf protein
    v-raf murine sarcoma viral oncogene homolog B1
    XP_038308737.1
    XP_038308738.1
    XP_038308739.1
    XP_038308740.1
    XP_038308741.1
    XP_038308742.1
    XP_038308743.1
    XP_038308744.1
    XP_038352975.1
    XP_038352976.1
    XP_038352977.1
    XP_038352978.1
    XP_038352979.1
    XP_038352980.1
    XP_038415313.1
    XP_038415314.1
    XP_038415315.1
    XP_038415316.1
    XP_038415317.1
    XP_038415318.1
    XP_038479294.1
    XP_038479295.1
    XP_038479296.1
    XP_038479297.1
    XP_038479298.1
    XP_038479299.1
    XP_038545012.1
    XP_038545013.1
    XP_038545014.1
    XP_038545015.1
    XP_038545016.1
    XP_038545017.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051820.1 Reference ROS_Cfam_1.0

      Range
      8065738..8237942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038689089.1 → XP_038545017.1  serine/threonine-protein kinase B-raf isoform X6

      UniProtKB/TrEMBL
      A0A8C0S060, A0A8I3SCX1, Q698R1
      Related
      ENSCAFP00845043393.1, ENSCAFT00845055177.1
      Conserved Domains (3) summary
      cd14062
      Location:499 → 751
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    2. XM_038689084.1 → XP_038545012.1  serine/threonine-protein kinase B-raf isoform X1

      UniProtKB/TrEMBL
      Q698R1
      Conserved Domains (3) summary
      cd14062
      Location:459 → 705
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    3. XM_038689085.1 → XP_038545013.1  serine/threonine-protein kinase B-raf isoform X2

      UniProtKB/TrEMBL
      A0A6B9SMP2, Q698R1
      Related
      ENSCAFP00845043390.1, ENSCAFT00845055173.1
      Conserved Domains (3) summary
      cd14062
      Location:459 → 711
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    4. XM_038689086.1 → XP_038545014.1  serine/threonine-protein kinase B-raf isoform X3

      UniProtKB/TrEMBL
      A0A8C0MIU3
      Conserved Domains (3) summary
      cd14062
      Location:459 → 661
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    5. XM_038689087.1 → XP_038545015.1  serine/threonine-protein kinase B-raf isoform X4

      UniProtKB/TrEMBL
      A0A8C0MIU3
      Conserved Domains (3) summary
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
      cl21453
      Location:459 → 616
      PKc_like; Protein Kinases, catalytic domain

    6. XM_038689088.1 → XP_038545016.1  serine/threonine-protein kinase B-raf isoform X5

      UniProtKB/TrEMBL
      A0A8C0L7C0
      Conserved Domains (3) summary
      cd14062
      Location:313 → 559
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cl00040
      Location:80 → 139
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
      cl28922
      Location:19 → 82
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049276.1 Alternate UMICH_Zoey_3.1

      Range
      8017140..8188930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038497052.1 → XP_038352980.1  serine/threonine-protein kinase B-raf isoform X6

      Conserved Domains (3) summary
      cd14062
      Location:499 → 751
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    2. XM_038497047.1 → XP_038352975.1  serine/threonine-protein kinase B-raf isoform X1

      Conserved Domains (3) summary
      cd14062
      Location:459 → 705
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    3. XM_038497048.1 → XP_038352976.1  serine/threonine-protein kinase B-raf isoform X2

      Conserved Domains (3) summary
      cd14062
      Location:459 → 711
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    4. XM_038497049.1 → XP_038352977.1  serine/threonine-protein kinase B-raf isoform X3

      Conserved Domains (3) summary
      cd14062
      Location:459 → 661
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    5. XM_038497050.1 → XP_038352978.1  serine/threonine-protein kinase B-raf isoform X4

      Conserved Domains (3) summary
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
      cl21453
      Location:459 → 616
      PKc_like; Protein Kinases, catalytic domain

    6. XM_038497051.1 → XP_038352979.1  serine/threonine-protein kinase B-raf isoform X5

      Conserved Domains (3) summary
      cd14062
      Location:313 → 559
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cl00040
      Location:80 → 139
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
      cl28922
      Location:19 → 82
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

      Range
      7861588..8033660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038623371.1 → XP_038479299.1  serine/threonine-protein kinase B-raf isoform X6

      Conserved Domains (3) summary
      cd14062
      Location:499 → 751
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    2. XM_038623366.1 → XP_038479294.1  serine/threonine-protein kinase B-raf isoform X1

      Conserved Domains (3) summary
      cd14062
      Location:459 → 705
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    3. XM_038623367.1 → XP_038479295.1  serine/threonine-protein kinase B-raf isoform X2

      Conserved Domains (3) summary
      cd14062
      Location:459 → 711
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    4. XM_038623368.1 → XP_038479296.1  serine/threonine-protein kinase B-raf isoform X3

      Conserved Domains (3) summary
      cd14062
      Location:459 → 661
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    5. XM_038623369.1 → XP_038479297.1  serine/threonine-protein kinase B-raf isoform X4

      Conserved Domains (3) summary
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
      cl21453
      Location:459 → 616
      PKc_like; Protein Kinases, catalytic domain

    6. XM_038623370.1 → XP_038479298.1  serine/threonine-protein kinase B-raf isoform X5

      Conserved Domains (3) summary
      cd14062
      Location:313 → 559
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cl00040
      Location:80 → 139
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
      cl28922
      Location:19 → 82
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

      Range
      7929505..8101841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038559390.1 → XP_038415318.1  serine/threonine-protein kinase B-raf isoform X6

      UniProtKB/TrEMBL
      A0A8C0S060, A0A8I3SCX1, Q698R1
      Conserved Domains (3) summary
      cd14062
      Location:499 → 751
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    2. XM_038559385.1 → XP_038415313.1  serine/threonine-protein kinase B-raf isoform X1

      UniProtKB/TrEMBL
      Q698R1
      Conserved Domains (3) summary
      cd14062
      Location:459 → 705
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    3. XM_038559386.1 → XP_038415314.1  serine/threonine-protein kinase B-raf isoform X2

      UniProtKB/TrEMBL
      A0A6B9SMP2, Q698R1
      Conserved Domains (3) summary
      cd14062
      Location:459 → 711
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    4. XM_038559387.1 → XP_038415315.1  serine/threonine-protein kinase B-raf isoform X3

      UniProtKB/TrEMBL
      A0A8C0MIU3
      Conserved Domains (3) summary
      cd14062
      Location:459 → 661
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    5. XM_038559388.1 → XP_038415316.1  serine/threonine-protein kinase B-raf isoform X4

      UniProtKB/TrEMBL
      A0A8C0MIU3
      Conserved Domains (3) summary
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
      cl21453
      Location:459 → 616
      PKc_like; Protein Kinases, catalytic domain

    6. XM_038559389.1 → XP_038415317.1  serine/threonine-protein kinase B-raf isoform X5

      UniProtKB/TrEMBL
      A0A8C0L7C0
      Conserved Domains (3) summary
      cd14062
      Location:313 → 559
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cl00040
      Location:80 → 139
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
      cl28922
      Location:19 → 82
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      8989501..9160850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038452815.1 → XP_038308743.1  serine/threonine-protein kinase B-raf isoform X6

      UniProtKB/TrEMBL
      A0A8C0S060, A0A8I3SCX1, Q698R1
      Conserved Domains (3) summary
      cd14062
      Location:499 → 751
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    2. XM_038452809.1 → XP_038308737.1  serine/threonine-protein kinase B-raf isoform X1

      UniProtKB/TrEMBL
      Q698R1
      Conserved Domains (3) summary
      cd14062
      Location:459 → 705
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    3. XM_038452811.1 → XP_038308739.1  serine/threonine-protein kinase B-raf isoform X2

      UniProtKB/TrEMBL
      A0A6B9SMP2, Q698R1
      Conserved Domains (3) summary
      cd14062
      Location:459 → 711
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    4. XM_038452816.1 → XP_038308744.1  serine/threonine-protein kinase B-raf isoform X8

      UniProtKB/TrEMBL
      Q698R1
      Conserved Domains (3) summary
      cd14062
      Location:499 → 751
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    5. XM_038452810.1 → XP_038308738.1  serine/threonine-protein kinase B-raf isoform X7

      UniProtKB/TrEMBL
      Q698R1
      Conserved Domains (3) summary
      cd14062
      Location:459 → 705
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    6. XM_038452812.1 → XP_038308740.1  serine/threonine-protein kinase B-raf isoform X3

      UniProtKB/TrEMBL
      A0A8C0MIU3
      Conserved Domains (3) summary
      cd14062
      Location:459 → 661
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    7. XM_038452813.1 → XP_038308741.1  serine/threonine-protein kinase B-raf isoform X4

      UniProtKB/TrEMBL
      A0A8C0MIU3
      Conserved Domains (3) summary
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
      cl21453
      Location:459 → 616
      PKc_like; Protein Kinases, catalytic domain

    8. XM_038452814.1 → XP_038308742.1  serine/threonine-protein kinase B-raf isoform X5

      UniProtKB/TrEMBL
      A0A8C0L7C0
      Conserved Domains (3) summary
      cd14062
      Location:313 → 559
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cl00040
      Location:80 → 139
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
      cl28922
      Location:19 → 82
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
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