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    CCR5 C-C motif chemokine receptor 5 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 450128, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CCR5provided by VGNC
    Official Full Name
    C-C motif chemokine receptor 5provided by VGNC
    Primary source
    VGNC:VGNC:11366
    Locus tag
    CK820_G0005233
    See related
    Ensembl:ENSPTRG00000014848
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human all
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    Genomic context

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    See CCR5 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 2 NC_086015.1 (50385079..50390439)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 3 NC_072401.1 (50386705..50387763)

    Chromosome 2 - NC_086015.1Genomic Context describing neighboring genes Neighboring gene cytochrome b-c1 complex subunit 2, mitochondrial-like Neighboring gene C-C motif chemokine receptor 2 Neighboring gene uncharacterized LOC104005543 Neighboring gene C-C motif chemokine receptor like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence of chemokine receptor gene CCR5 in chimpanzees, a natural HIV type 1 host. Zacharova V, et al. AIDS Res Hum Retroviruses, 1997 Sep 1. PMID 9282822
    2. Sequence evolution of the CCR5 chemokine receptor gene in primates. Zhang YW, et al. Mol Biol Evol, 1999 Sep. PMID 10486970
    3. Chimpanzee CXCR4 and CCR5 act as coreceptors for HIV type 1. Prétet JL, et al. AIDS Res Hum Retroviruses, 1997 Dec 10. PMID 9430250
    4. HIV type 1 subtypes, coreceptor usage, and CCR5 polymorphism. Zhang L, et al. AIDS Res Hum Retroviruses, 1997 Nov 1. PMID 9359654
    5. Structure and function of CC-chemokine receptor 5 homologues derived from representative primate species and subspecies of the taxonomic suborders Prosimii and Anthropoidea. Kunstman KJ, et al. J Virol, 2003 Nov. PMID 14581567, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables C-C chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables chemokine (C-C motif) ligand 5 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-C chemokine receptor type 5
    Names
    C-C CKR-5
    C-C chemokine receptor 5
    CC chemokine receptor type 5
    CC-CKR-5
    CC-chemokine receptor 5
    CCR-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009046.1 → NP_001009046.1  C-C chemokine receptor type 5

      See identical proteins and their annotated locations for NP_001009046.1

      Status: PROVISIONAL

      Source sequence(s)
      AF177894
      UniProtKB/Swiss-Prot
      O02778, P56440
      UniProtKB/TrEMBL
      A0A0E3T4M2, A0A2J8PAG3, A0A2L2P6L9
      Related
      ENSPTRP00000025599.5, ENSPTRT00000027757.6
      Conserved Domains (1) summary
      cd15184
      Location:31 → 308
      7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_086015.1 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      50385079..50390439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063805076.1 → XP_063661146.1  C-C chemokine receptor type 5 isoform X1

      UniProtKB/Swiss-Prot
      O02778, P56440
      UniProtKB/TrEMBL
      A0A0E3T4M2, A0A2J8PAG3, A0A2L2P6L9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56440.1 GenPept UniProtKB/Swiss-Prot:P56440

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials