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    CD4 CD4 molecule [ Pan troglodytes (chimpanzee) ]

    Gene ID: 450124, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CD4provided by VGNC
    Official Full Name
    CD4 moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:5330
    Locus tag
    CK820_G0048139
    See related
    Ensembl:ENSPTRG00000004590
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See CD4 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 10 NC_072408.2 (13971855..14003044)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 12 NC_072410.1 (12621584..12652819)

    Chromosome 10 - NC_072408.2Genomic Context describing neighboring genes Neighboring gene myeloid leukemia factor 2 Neighboring gene parathymosin Neighboring gene lymphocyte activating 3 Neighboring gene G protein-coupled receptor 162 Neighboring gene prolyl 3-hydroxylase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A glycan shield on chimpanzee CD4 protects against infection by primate lentiviruses (HIV/SIV). Warren CJ, et al. Proc Natl Acad Sci U S A, 2019 Jun 4. PMID 31113887, Free PMC Article
    2. Genetic subspecies diversity of the chimpanzee CD4 virus-receptor gene. Hvilsom C, et al. Genomics, 2008 Nov. PMID 18718520
    3. A CD4 domain important for HIV-mediated syncytium formation lies outside the virus binding site. Camerini D, et al. Cell, 1990 Mar 9. PMID 2107024
    4. Cloning and sequences of primate CD4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency virus. Fomsgaard A, et al. Eur J Immunol, 1992 Nov. PMID 1425921

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in interleukin-15-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-cell surface glycoprotein CD4
    Names
    CD4 antigen (p55)
    T-cell surface antigen T4/Leu-3
    lymphocyte antigen CD4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009043.1 → NP_001009043.1  T-cell surface glycoprotein CD4 precursor

      See identical proteins and their annotated locations for NP_001009043.1

      Status: PROVISIONAL

      Source sequence(s)
      M31135
      UniProtKB/Swiss-Prot
      P16004
      UniProtKB/TrEMBL
      A0A0E3T6P3, A0A2J8JEL8, A0A410S7F1, A0A4P9Q224, A0A663D762, B0LAF4, B0LAH5, B0LAI4, K7AM69
      Related
      ENSPTRP00000054833.3, ENSPTRT00000062277.3
      Conserved Domains (5) summary
      cd07690
      Location:28 → 121
      Ig1_CD4; First immunoglobulin (Ig) domain of CD4
      cd07694
      Location:123 → 204
      Ig2_CD4; Second immunoglobulin (Ig) domain of CD4
      pfam12104
      Location:426 → 453
      Tcell_CD4_C; T cell CD4 receptor C terminal region
      pfam05790
      Location:317 → 389
      C2-set; Immunoglobulin C2-set domain
      pfam09191
      Location:208 → 316
      CD4-extracel; CD4, extracellular

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      13971855..14003044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016922513.4 → XP_016778002.1  T-cell surface glycoprotein CD4 isoform X2

    2. XM_016922510.4 → XP_016777999.1  T-cell surface glycoprotein CD4 isoform X1

      UniProtKB/Swiss-Prot
      P16004
      UniProtKB/TrEMBL
      A0A0E3T6P3, A0A2J8JEL8, A0A410S7F1, A0A4P9Q224, A0A663D762, B0LAF4, B0LAH5, B0LAI4, K7AM69
      Conserved Domains (5) summary
      cd07690
      Location:28 → 121
      Ig1_CD4; First immunoglobulin (Ig) domain of CD4
      cd07694
      Location:123 → 204
      Ig2_CD4; Second immunoglobulin (Ig) domain of CD4
      pfam12104
      Location:426 → 453
      Tcell_CD4_C; T cell CD4 receptor C terminal region
      pfam05790
      Location:317 → 389
      C2-set; Immunoglobulin C2-set domain
      pfam09191
      Location:208 → 316
      CD4-extracel; CD4, extracellular
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16004.1 GenPept UniProtKB/Swiss-Prot:P16004

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials