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    ERVK-7 endogenous retrovirus group K member 7 [ Homo sapiens (human) ]

    Gene ID: 449619, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ERVK-7provided by HGNC
    Official Full Name
    endogenous retrovirus group K member 7provided by HGNC
    Primary source
    HGNC:HGNC:31828
    See related
    MIM:614013; AllianceGenome:HGNC:31828
    Gene type
    other
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERVK7; HERV-K102; HERV-KIII; HERV-K(III)
    Summary
    Predicted to enable RNA stem-loop binding activity. Predicted to be involved in DNA metabolic process; proteolysis; and viral translational frameshifting. Predicted to be located in nucleus and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    Location:
    1q22

    Bibliography

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    Related articles in PubMed

    1. The replicative activity of human endogenous retrovirus K102 (HERV-K102) with HIV viremia. Laderoute MP, et al. AIDS, 2007 Nov 30. PMID 18025878
    2. Neither an intronic CA repeat within the CD48 gene nor the HERV-K18 polymorphisms are associated with type 1 diabetes. Ramos-Lopez E, et al. Tissue Antigens, 2006 Aug. PMID 16866884
    3. Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans. Barbulescu M, et al. Curr Biol, 1999 Aug 26. PMID 10469592
    4. Quantitation of HERV-K env gene expression and splicing in human breast cancer. Wang-Johanning F, et al. Oncogene, 2003 Mar 13. PMID 12629516
    5. Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping. Sugimoto J, et al. Genomics, 2001 Mar 1. PMID 11401426

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Replication-competent, particle producing, HERV-K HML-2 Type I retrovirus with foamy-virus-like properties;innate host defence mechanism to bloodborne pathogens with temporary T and B cell responses to Env
      Title: The replicative activity of human endogenous retrovirus K102 (HERV-K102) with HIV viremia.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Neither an intronic CA repeat within the CD48 gene nor the HERV-K18 polymorphisms are associated with type 1 diabetes.
    Submit: New GeneRIF Correction

    General gene information

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    Other Names

    • Endogenous retrovirus group K member 7 Gag polyprotein
    • Endogenous retrovirus group K member 7 Np9 protein
    • Endogenous retrovirus group K member 7 Pol protein
    • Endogenous retrovirus group K member 7 Pro protein
    • HERV-K(III) Gag protein
    • HERV-K(III) Np9 protein
    • HERV-K(III) Pol protein
    • HERV-K(III) Pro protein
    • HERV-K102 Gag protein
    • HERV-K102 Np9 protein
    • HERV-K102 Pol protein
    • HERV-K102 Pro protein
    • HERV-K_1q22 provirus Np9 protein
    • HERV-K_1q22 provirus ancestral Env polyprotein
    • HERV-K_1q22 provirus ancestral Gag polyprotein
    • HERV-K_1q22 provirus ancestral Pol protein
    • HERV-K_1q22 provirus ancestral Pro protein
    • endogenous retroviral sequence K, 7 (type 2)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA stem-loop binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA integration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA synthesis involved in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA-templated DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in viral process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in viral translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61567.1 GenPept UniProtKB/Swiss-Prot:P61567
    P61582.1 GenPept UniProtKB/Swiss-Prot:P61582
    P63130.2 GenPept UniProtKB/Swiss-Prot:P63130
    P63131.1 GenPept UniProtKB/Swiss-Prot:P63131
    P63135.1 GenPept UniProtKB/Swiss-Prot:P63135

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