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    CCND1 cyclin D1 [ Canis lupus familiaris (dog) ]

    Gene ID: 449028, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CCND1provided by VGNC
    Official Full Name
    cyclin D1provided by VGNC
    Primary source
    VGNC:VGNC:54266
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    human mouse all
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    Genomic context

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    See CCND1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (49179073..49188648, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (47111842..47121415, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (48958012..48967584, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (48625670..48635233, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (48211983..48221555, complement)

    Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102157232 Neighboring gene LTO1 maturation factor of ABCE1 Neighboring gene uncharacterized LOC102157321 Neighboring gene uncharacterized LOC111090987

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cyclin D1 immunohistochemical expression and somatic mutations in canine oral melanoma. Zamboni C, et al. Vet Comp Oncol, 2020 Jun. PMID 31503380
    2. Prognostic significance of surgical margin, Ki-67 and cyclin D1 protein expression in grade II canine cutaneous mast cell tumor. Ozaki K, et al. J Vet Med Sci, 2007 Nov. PMID 18057825
    3. Molecular characterization and mapping of the canine cyclin D1 (CCND1) gene. Meyer B, et al. Anim Genet, 2004 Oct. PMID 15373750
    4. Zona occludens-2 inhibits cyclin D1 expression and cell proliferation and exhibits changes in localization along the cell cycle. Tapia R, et al. Mol Biol Cell, 2009 Feb. PMID 19056685, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cyclin D1 immunohistochemical expression and somatic mutations in canine oral melanoma.
      Title: Cyclin D1 immunohistochemical expression and somatic mutations in canine oral melanoma.
    2. ZO-2 inhibits cell proliferation at G0/G1 and decreases CD1 protein level.
      Title: Zona occludens-2 inhibits cyclin D1 expression and cell proliferation and exhibits changes in localization along the cell cycle.
    3. The prognostic value of surgical margins, Ki-67 and cyclin D1 expression in the determination of prognosis in canine cutaneous mast cell tumor are reported.
      Title: Prognostic significance of surgical margin, Ki-67 and cyclin D1 protein expression in grade II canine cutaneous mast cell tumor.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G1/S-specific cyclin-D1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005757.1 → NP_001005757.1  G1/S-specific cyclin-D1

      See identical proteins and their annotated locations for NP_001005757.1

      Status: PROVISIONAL

      Source sequence(s)
      AY620434
      UniProtKB/Swiss-Prot
      Q64HP0
      Conserved Domains (2) summary
      pfam00134
      Location:31 → 153
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:156 → 270
      Cyclin_C; Cyclin, C-terminal domain

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051822.1 Reference ROS_Cfam_1.0

      Range
      49179073..49188648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049278.1 Alternate UMICH_Zoey_3.1

      Range
      48625670..48635233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

      Range
      48211983..48221555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

      Range
      48958012..48967584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      47111842..47121415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64HP0.1 GenPept UniProtKB/Swiss-Prot:Q64HP0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials