CFL1 cofilin 1 [Sus scrofa (pig)] - Gene

Summary

Gene symbol: CFL1
Gene description: cofilin 1
See related: Ensembl:ENSSSCG00000012974
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: COFILIN
Annotation information: Annotation category: partial on reference assembly
Expression: Ubiquitous expression in spleen (RPKM 554.1), lung (RPKM 431.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	2	NC_010444.4 (6471558..6475019)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	2	NC_010444.3 (5575587..5579048)

Chromosome 2 - NC_010444.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vitro, formation of cofilin oligomers was drastically reduced after phosphorylation by LIMK2.
Title: Cofilin oligomer formation occurs in vivo and is regulated by cofilin phosphorylation.
Cofilin is necessary for maintaining the osmotic responsiveness of the cytoskeleton in tubular cells, and the Rho/ROCK/LIMK-mediated cofilin phosphorylation is a key mechanism in the hyperosmotic stress-induced F-actin increase.
Title: Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response.
glucose increases p-cofilin by phosphorylating LIMK1 through activation of Rho/Rho kinase, probably due to diacylglycerol-sensitive PKC activation resulting from increased glucose influx
Title: High glucose increases phosphocofilin via phosphorylation of LIM kinase due to Rho/Rho kinase activation in cultured pig proximal tubular epithelial cells.

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General gene information

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Markers

CFL1 (e-PCR)
- UniSTS:254031

MARC_23793-23794:1027526010:3 (e-PCR)
- UniSTS:268775

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables actin filament binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament fragmentation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in actin filament severing	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell motility	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in actin cortical patch	IEA Inferred from Electronic Annotation more info	PubMed
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cofilin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.