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    TGFB1 transforming growth factor beta 1 [ Ovis aries (sheep) ]

    Gene ID: 443417, updated on 12-May-2024

    Summary

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    Gene symbol
    TGFB1
    Gene description
    transforming growth factor beta 1
    See related
    EnsemblRapid:ENSOARG00020017842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 14 NC_056067.1 (50043066..50062674, complement)

    Chromosome 14 - NC_056067.1Genomic Context describing neighboring genes Neighboring gene AXL receptor tyrosine kinase Neighboring gene heterogeneous nuclear ribonucleoprotein U like 1 Neighboring gene coiled-coil domain containing 97 Neighboring gene B9 domain containing 2 Neighboring gene transmembrane protein 91 Neighboring gene exosome component 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056067.1 Chromosome 14 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Using sheep lines with mutations in single genes to better understand ovarian function. Juengel JL, et al. Reproduction, 2013 Oct. PMID 23801782
    2. Inhibitor of differentiation (Id) genes are expressed in the steroidogenic cells of the ovine ovary and are differentially regulated by members of the transforming growth factor-beta family. Hogg K, et al. Endocrinology, 2010 Mar. PMID 20032053, Free PMC Article
    3. Antenatal inflammation induced TGF-beta1 but suppressed CTGF in preterm lungs. Kunzmann S, et al. Am J Physiol Lung Cell Mol Physiol, 2007 Jan. PMID 16936247
    4. Sequence and chromosomal localisation of the gene encoding ovine latent transforming growth factor-beta 1. Woodall CJ, et al. Gene, 1994 Dec 15. PMID 7821809
    5. IL-10 and TGF-beta1 are associated with variations in fluke burdens following experimental fasciolosis in sheep. Haçariz O, et al. Parasite Immunol, 2009 Oct. PMID 19751473

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transforming growth factor-beta1 mediates the SMAD4/BMF pathway to regulate ovarian granulosa cell apoptosis in small tail Han sheep.
      Title: Transforming growth factor-β1 mediates the SMAD4/BMF pathway to regulate ovarian granulosa cell apoptosis in small tail Han sheep.
    2. In the 2 different muscle tissues, expression of Smad2 was significantly positively correlated (P < 0.01) with that of Smad3. The expression of Smad3 was significantly positively correlated (P < 0.01) with that of Smad4, which showed that the Smad family genes could have an inhibitory effect on the TGF-beta/Smad signaling pathway.
      Title: Analysis of the spatiotemporal expression of major genes in the TGF-β/Smad signaling pathway and correlation analysis using Hu sheep muscle tissue.
    3. Mutations in transforming Growth Factor beta is associated with ovulation
      Title: Using sheep lines with mutations in single genes to better understand ovarian function.
    4. TGFbeta signaling can regulate Inhibitor of differentiation gene expression in the sheep ovarian follicle.
      Title: Inhibitor of differentiation (Id) genes are expressed in the steroidogenic cells of the ovine ovary and are differentially regulated by members of the transforming growth factor-beta family.
    5. Significant differences in mitogen-specific lymphocyte proliferation in vitro and in expression of TGF-beta1 and IL-10 genes in hepatic lymph nodes were observed at acute and chronic phases of infection, respectively.
      Title: IL-10 and TGF-beta1 are associated with variations in fluke burdens following experimental fasciolosis in sheep.
    6. antenatal inflammation-induced TGF-beta1 expression and Smad signaling in the fetal lung may contribute to impaired lung alveolarization and reduced lung inflammation
      Title: Antenatal inflammation induced TGF-beta1 but suppressed CTGF in preterm lungs.
    7. mRNA encoding both TGF-beta 1 and 2 were synthesized by ovarian theca, stroma and cells of the vascular system whereas TGF-beta 3 mRNA was synthesized by vascular cells
      Title: The role of transforming growth factor-beta (TGF-beta) during ovarian follicular development in sheep.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables type II transforming growth factor beta receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables type III transforming growth factor beta receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transforming growth factor beta-1 proprotein
    Names
    TGF-beta 1
    transforming growth factor, beta 1 (Camurati-Engelmann disease)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009400.2 → NP_001009400.1  transforming growth factor beta-1 proprotein precursor

      See identical proteins and their annotated locations for NP_001009400.1

      Status: VALIDATED

      Source sequence(s)
      JAEVFA010000120, X76916
      UniProtKB/Swiss-Prot
      P50414
      UniProtKB/TrEMBL
      W5PC52
      Conserved Domains (2) summary
      smart00204
      Location:293 → 390
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:29 → 261
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056067.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      50043066..50062674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_042230710.2 → XP_042086644.1  transforming growth factor beta-1 proprotein isoform X2

      UniProtKB/TrEMBL
      W5PC52
      Related
      ENSOARP00020060140.1, ENSOART00020045579.1
      Conserved Domains (1) summary
      cl40434
      Location:292 → 338
      TGF_beta_SF; transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily

    2. XM_042230708.2 → XP_042086642.1  transforming growth factor beta-1 proprotein isoform X1

      UniProtKB/TrEMBL
      W5PC52
      Conserved Domains (1) summary
      cl40434
      Location:293 → 339
      TGF_beta_SF; transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily

    3. XM_027977372.3 → XP_027833173.1  transforming growth factor beta-1 proprotein isoform X3

      UniProtKB/TrEMBL
      W5PC52
      Related
      ENSOARP00020022795.2, ENSOART00020027474.2
      Conserved Domains (2) summary
      cd19384
      Location:293 → 391
      TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
      pfam00688
      Location:30 → 262
      TGFb_propeptide; TGF-beta propeptide
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50414.1 GenPept UniProtKB/Swiss-Prot:P50414

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials