ELANE elastase, neutrophil expressed [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ELANEprovided by VGNC
Official Full Name: elastase, neutrophil expressedprovided by VGNC
Primary source: VGNC:VGNC:108243
See related: Ensembl:ENSCAFG00845014549
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: ELA2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	20	NC_051824.1 (58531328..58533216, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	20	NC_006602.4 (57591060..57592948, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	20	NC_049241.1 (58268788..58270676, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	20	NC_049280.1 (57586105..57588011, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	20	NC_049761.1 (58065758..58067646, complement)

Chromosome 20 - NC_051824.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

neutrophil elastase mutations play a role in hereditary neutropenia, as shown in the dog model [review]
Title: Hereditary neutropenia: dogs explain human neutrophil elastase mutations.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in acute inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: neutrophil elastase

Names: elastase 2, neutrophil; serine protease

NP_001003378.1

EC 3.4.21.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003378.2 → NP_001003378.1 neutrophil elastase precursor

See identical proteins and their annotated locations for NP_001003378.1

Status: PROVISIONAL

Source sequence(s)

AF494190

UniProtKB/TrEMBL

A0A8C0NSC8, A0A8C0YUX9, A0A8P0NL41, F1PF12, Q8MJD1

Related

ENSCAFP00845020524.1, ENSCAFT00845026031.1

Conserved Domains (2) summary

smart00020
Location:30 → 243

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:31 → 246

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...