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    CDH1 cadherin 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 442858, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CDH1provided by VGNC
    Official Full Name
    cadherin 1provided by VGNC
    Primary source
    VGNC:VGNC:53314
    See related
    Ensembl:ENSCAFG00845010704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    Cadherin-1; Uvomorulin
    Orthologs
    human mouse all
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    Genomic context

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    See CDH1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (81192046..81269949, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (80748132..80825726, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (81341865..81420857, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (81019133..81096989, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (80702291..80780290, complement)

    Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene transport and golgi organization 6 homolog Neighboring gene mesoderm-specific transcript homolog protein-like Neighboring gene ragulator complex protein LAMTOR1-like Neighboring gene peroxiredoxin-1-like Neighboring gene cadherin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cadherin puncta are interdigitated dynamic actin protrusions necessary for stable cadherin adhesion. Li JXH, et al. Proc Natl Acad Sci U S A, 2021 Jun 15. PMID 34099568, Free PMC Article
    2. Calcium site mutations in cadherin: impact on adhesion and evidence of cooperativity. Prakasam A, et al. Biochemistry, 2006 Jun 6. PMID 16734428
    3. Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cells. Capaldo CT, et al. Mol Biol Cell, 2007 Jan. PMID 17093058, Free PMC Article
    4. Sialyl Lewis x expression in canine malignant mammary tumours: correlation with clinicopathological features and E-Cadherin expression. Pinho SS, et al. BMC Cancer, 2007 Jul 6. PMID 17617904, Free PMC Article
    5. E-cadherin expression in canine cutaneous histiocytomas. Baines SJ, et al. Vet Rec, 2008 Apr 19. PMID 18424847

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cadherin puncta are interdigitated dynamic actin protrusions necessary for stable cadherin adhesion.
      Title: Cadherin puncta are interdigitated dynamic actin protrusions necessary for stable cadherin adhesion.
    2. the generation of a shear-induced mechanical event at the shear plane is relayed across the epithelium by actomyosin contraction linked through E-cadherin.
      Title: Shear-induced damped oscillations in an epithelium depend on actomyosin contraction and E-cadherin cell adhesion.
    3. Src- and confinement-dependent FAK activation causes E-cadherin relaxation and beta-catenin activity.
      Title: Src- and confinement-dependent FAK activation causes E-cadherin relaxation and β-catenin activity.
    4. Results show that cadherin-1 drives type I collagen organization and invadopodia activity in pancreatic ductal adenocarcinoma (PDAC). Also, s significant amount of cadherin-1 remains expressed at the cell surface during tumorigenesis.
      Title: Cadherin-1 and cadherin-3 cooperation determines the aggressiveness of pancreatic ductal adenocarcinoma.
    5. E-cadherin plays a key role in sensing polarized tensile forces across the tissue and transducing this information to the spindle orientation machinery to align cell divisions.
      Title: E-cadherin and LGN align epithelial cell divisions with tissue tension independently of cell shape.
    6. The results show the existence of a softening of the adherens junctional complex in progestagen-dominated stages favoring embryo-maternal interactions and endometrial invasion during canine implantation.
      Title: Immunolocalization of E-cadherin and β-catenin in the cyclic and early pregnant canine endometrium.
    7. ZEB1 appears to not exert E-cadherin transcriptional repression activity
      Title: The Relationship Between E-Cadherin and its Transcriptional Repressors in Spontaneously Arising Canine Invasive Micropapillary Mammary Carcinoma.
    8. All the hyperplastic samples stained positive for both markers, 100% of adenomas were positive for PTEN and 86% for E-cadherin, and 69% and 34% of carcinomas were positive for PTEN and E-cadherin, respectively.
      Title: Co-localization of PTEN and E-cadherin in canine mammary hyperplasias and benign and malignant mammary tumors.
    9. Epithelial cells with disrupted E-cadherin gene retain the ability to form cell junctions and apico-basal polarity.
      Title: Epithelial DLD-1 Cells with Disrupted E-cadherin Gene Retain the Ability to Form Cell Junctions and Apico-basal Polarity.
    10. the allosteric regulation of cell surface E-cadherin by p120(ctn) dephosphorylation.
      Title: Allosteric Regulation of E-Cadherin Adhesion.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of catenin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cadherin-1
    Names
    E-cadherin
    Epithelial cadherin
    cadherin 1, type 1, E-cadherin (epithelial)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287125.2 → NP_001274054.1  cadherin-1 precursor

      See identical proteins and their annotated locations for NP_001274054.1

      Status: VALIDATED

      Source sequence(s)
      JAAUVH010000371
      UniProtKB/Swiss-Prot
      F1PAA9
      UniProtKB/TrEMBL
      A0A8I3NBM1, A0A8P0SPD4
      Related
      ENSCAFP00845014829.1, ENSCAFT00845018984.1
      Conserved Domains (5) summary
      cd00031
      Location:160 → 260
      CA_like; Cadherin repeat-like domain
      cd11304
      Location:494 → 593
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:744 → 880
      Cadherin_C; Cadherin cytoplasmic region
      pfam08758
      Location:31 → 120
      Cadherin_pro; Cadherin prodomain like
      cl09101
      Location:608 → 688
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051809.1 Reference ROS_Cfam_1.0

      Range
      81192046..81269949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049265.1 Alternate UMICH_Zoey_3.1

      Range
      81019133..81096989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

      Range
      80702291..80780290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

      Range
      81341865..81420857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      80748132..80825726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1PAA9.2 GenPept UniProtKB/Swiss-Prot:F1PAA9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.