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    Rab44 RAB44, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 442827, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rab44provided by MGI
    Official Full Name
    RAB44, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:3045302
    See related
    Ensembl:ENSMUSG00000064147 AllianceGenome:MGI:3045302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9830134C10Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within histamine secretion by mast cell and histamine secretion mediated by IgE immunoglobulin. Predicted to be located in plasma membrane. Orthologous to human RAB44 (RAB44, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 6.4), lung adult (RPKM 3.8) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rab44 in Genome Data Viewer
    Location:
    17 A3.3; 17 15.14 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29333102..29367966)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29114128..29148980)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42251 Neighboring gene tumor protein p53 pathway corepressor 1 Neighboring gene predicted gene, 41556 Neighboring gene STARR-seq mESC enhancer starr_42255 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29218945-29219128 Neighboring gene STARR-seq mESC enhancer starr_42257 Neighboring gene STARR-seq mESC enhancer starr_42258 Neighboring gene STARR-positive B cell enhancer mm9_chr17:29239826-29240127 Neighboring gene cyclin dependent kinase inhibitor 1A Neighboring gene STARR-positive B cell enhancer mm9_chr17:29243389-29243689 Neighboring gene STARR-positive B cell enhancer mm9_chr17:29243839-29244139 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29255128-29255329 Neighboring gene STARR-seq mESC enhancer starr_42259 Neighboring gene ribosomal protein L35A, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_42262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29301422-29301531 Neighboring gene somatostatin receptor 4 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8663 Neighboring gene copine V Neighboring gene STARR-positive B cell enhancer ABC_E10943 Neighboring gene STARR-seq mESC enhancer starr_42268

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large Rab GTPase Rab44 regulates microtubule-dependent retrograde melanosome transport in melanocytes. Maruta Y, et al. J Biol Chem, 2022 Nov. PMID 36126775, Free PMC Article
    2. The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis. Kadowaki T, et al. Cell Mol Immunol, 2020 Dec. PMID 32238914, Free PMC Article
    3. Rab44 Deficiency Induces Impaired Immune Responses to Nickel Allergy. Noguromi M, et al. Int J Mol Sci, 2023 Jan 4. PMID 36674510, Free PMC Article
    4. Rab44 regulates murine mast cell-driven anaphylaxis through kinesin-1-dependent secretory granule translocation. Longé C, et al. J Allergy Clin Immunol, 2022 Sep. PMID 35469841
    5. Rab44 isoforms similarly promote lysosomal exocytosis, but exhibit differential localization in mast cells. Kadowaki T, et al. FEBS Open Bio, 2021 Apr. PMID 33641252, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rab44 Deficiency Induces Impaired Immune Responses to Nickel Allergy.
      Title: Rab44 Deficiency Induces Impaired Immune Responses to Nickel Allergy.
    2. Large Rab GTPase Rab44 regulates microtubule-dependent retrograde melanosome transport in melanocytes.
      Title: Large Rab GTPase Rab44 regulates microtubule-dependent retrograde melanosome transport in melanocytes.
    3. Rab44 regulates murine mast cell-driven anaphylaxis through kinesin-1-dependent secretory granule translocation.
      Title: Rab44 regulates murine mast cell-driven anaphylaxis through kinesin-1-dependent secretory granule translocation.
    4. Rab44 isoforms similarly promote lysosomal exocytosis, but exhibit differential localization in mast cells.
      Title: Rab44 isoforms similarly promote lysosomal exocytosis, but exhibit differential localization in mast cells.
    5. The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis.
      Title: The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis.
    6. Data show that Rab GTPase Rab44 affects nuclear factor of activated T-cells c1 (NFATc1) signaling in RANKL-stimulated macrophages.
      Title: Rab44, a novel large Rab GTPase, negatively regulates osteoclast differentiation by modulating intracellular calcium levels followed by NFATc1 activation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within histamine secretion by mast cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within histamine secretion mediated by IgE immunoglobulin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-44

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364848.1 → NP_001351777.1  ras-related protein Rab-44

      Status: VALIDATED

      Source sequence(s)
      AC167363, BY203725
      Consensus CDS
      CCDS37535.2
      UniProtKB/Swiss-Prot
      B9EID0, Q8CB87
      Related
      ENSMUSP00000156400.2, ENSMUST00000233717.2
      Conserved Domains (4) summary
      cd00154
      Location:788 → 944
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      PHA03247
      Location:425 → 783
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:173 → 353
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:45 → 101
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      29333102..29367966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160678.1 → XP_036016571.1  ras-related protein Rab-44 isoform X2

      Conserved Domains (3) summary
      cd00154
      Location:788 → 910
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      COG1196
      Location:160 → 337
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam03154
      Location:422 → 745
      Atrophin-1; Atrophin-1 family

    2. XM_006524598.3 → XP_006524661.1  ras-related protein Rab-44 isoform X8

      Conserved Domains (3) summary
      cd00154
      Location:363 → 519
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      TIGR02168
      Location:161 → 341
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:45 → 101
      EF-hand_7; EF-hand domain pair

    3. XM_006524593.3 → XP_006524656.1  ras-related protein Rab-44 isoform X3

      Conserved Domains (4) summary
      cd00154
      Location:739 → 895
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      PHA03247
      Location:376 → 734
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:178 → 304
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:45 → 101
      EF-hand_7; EF-hand domain pair

    4. XM_006524595.1 → XP_006524658.1  ras-related protein Rab-44 isoform X5

      Conserved Domains (4) summary
      PHA03247
      Location:425 → 783
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:173 → 353
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:45 → 101
      EF-hand_7; EF-hand domain pair
      cl38936
      Location:788 → 846
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_011246529.2 → XP_011244831.1  ras-related protein Rab-44 isoform X1

      See identical proteins and their annotated locations for XP_011244831.1

      UniProtKB/Swiss-Prot
      B9EID0, Q8CB87
      Conserved Domains (4) summary
      cd00154
      Location:788 → 944
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      PHA03247
      Location:425 → 783
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:173 → 353
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:45 → 101
      EF-hand_7; EF-hand domain pair

    6. XM_006524596.5 → XP_006524659.1  ras-related protein Rab-44 isoform X6

      Conserved Domains (3) summary
      cd00154
      Location:633 → 789
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      PHA03247
      Location:270 → 628
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:18 → 198
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    7. XM_006524594.3 → XP_006524657.1  ras-related protein Rab-44 isoform X4

      Conserved Domains (3) summary
      cd00154
      Location:706 → 862
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      PHA03247
      Location:343 → 701
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:91 → 271
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. XM_006524597.5 → XP_006524660.1  ras-related protein Rab-44 isoform X7

      See identical proteins and their annotated locations for XP_006524660.1

      UniProtKB/TrEMBL
      A0A2Y9CZI3
      Related
      ENSMUSP00000085253.5, ENSMUST00000087942.6
      Conserved Domains (3) summary
      cd00154
      Location:540 → 696
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      PHA03247
      Location:177 → 535
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:7 → 105
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001002786.2: Suppressed sequence

      Description
      NM_001002786.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CB87.2 GenPept UniProtKB/Swiss-Prot:Q8CB87

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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