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    fan farinelli [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43926, updated on 18-Sep-2024

    Summary

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    Official Symbol
    fanprovided by FlyBase
    Official Full Name
    farinelliprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028379
    Locus tag
    Dmel_CG7919
    See related
    AllianceGenome:FB:FBgn0028379
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7919; Dmel\CG7919; dVAP-C; FAN
    Summary
    Predicted to enable FFAT motif binding activity. Involved in sperm individualization. Located in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPB (VAMP associated protein B and C). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See fan in Genome Data Viewer
    Location:
    66B6-66B6; 3-22 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8109132..8110043)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8102232..8103143)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Sterile alpha and Armadillo motif Neighboring gene long non-coding RNA:CR43974 Neighboring gene uncharacterized protein Neighboring gene mir-2501 stem loop Neighboring gene Nuclear localized protein 1 Neighboring gene Actin-related protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RDGBα localization and function at membrane contact sites is regulated by FFAT-VAP interactions. Yadav S, et al. J Cell Sci, 2018 Jan 8. PMID 29180517, Free PMC Article
    2. OSBP- and FAN-mediated sterol requirement for spermatogenesis in Drosophila. Ma Z, et al. Development, 2010 Nov. PMID 20943709
    3. hVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its Drosophila homologue DVAP-33A at the neuromuscular junction. Chai A, et al. Hum Mol Genet, 2008 Jan 15. PMID 17947296, Free PMC Article
    4. Analysis of the Drosophila melanogaster testes transcriptome reveals coordinate regulation of paralogous genes. Mikhaylova LM, et al. Genetics, 2008 May. PMID 18493055, Free PMC Article
    5. Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner. Pennetta G, et al. Neuron, 2002 Jul 18. PMID 12160747

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study identified an OSBP- and FAN-mediated sterol requirement in Drosophila spermatogenesis
      Title: OSBP- and FAN-mediated sterol requirement for spermatogenesis in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum-plasma membrane tethering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    farinelli
    Names
    CG7919-PA
    fan-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8109132..8110043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079918.3 → NP_524657.2  farinelli [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524657.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NAX1, Q9VSD3
      Related
      FBpp0076406
      Conserved Domains (1) summary
      pfam00635
      Location:8 → 114
      Motile_Sperm; MSP (Major sperm protein) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSD3 Q9VSD3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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