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    N nucleocapsid phosphoprotein [ Severe acute respiratory syndrome coronavirus 2 ]

    Gene ID: 43740575, updated on 3-Nov-2024

    Summary

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    Gene symbol
    N
    Gene description
    nucleocapsid phosphoprotein
    Locus tag
    GU280_gp10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Severe acute respiratory syndrome coronavirus 2 (isolate: Wuhan-Hu-1, nat-host: Homo sapiens)
    Lineage
    Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
    Summary
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ The structural proteins of SARS-CoV-2 include the envelope protein (E), spike or surface glycoprotein (S), membrane protein (M) and the nucleocapsid protein (N). The nucleocapsid phosphoprotein is a structural protein that binds to, protects the viral RNA genome and is involved in packaging the RNA into virus particles. The N protein has been suggested as an antiviral drug target.
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    Genomic context

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    Sequence:
    NC_045512.2 (28274..29533)

    NC_045512.2Genomic Context describing neighboring genes Neighboring gene ORF7a protein Neighboring gene ORF7b Neighboring gene ORF8 protein Neighboring gene ORF10 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_045512.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [1]H, [15]N, and [13]C resonance assignments of the N-terminal domain and ser-arg-rich intrinsically disordered region of the nucleocapsid protein of the SARS-CoV-2.
      Title: (1)H, (15)N, and (13)C resonance assignments of the N-terminal domain and ser-arg-rich intrinsically disordered region of the nucleocapsid protein of the SARS-CoV-2.
    2. Energetic and frustration analysis of SARS-CoV-2 nucleocapsid protein mutations.
      Title: Energetic and frustration analysis of SARS-CoV-2 nucleocapsid protein mutations.
    3. Metabolic and mitochondria alterations induced by SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10.
      Title: Metabolic and mitochondria alterations induced by SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10.
    4. Assembly of SARS-CoV-2 nucleocapsid protein with nucleic acid.
      Title: Assembly of SARS-CoV-2 nucleocapsid protein with nucleic acid.
    5. TRIM6 facilitates SARS-CoV-2 proliferation by catalyzing the K29-typed ubiquitination of NP to enhance the ability to bind viral genomes.
      Title: TRIM6 facilitates SARS-CoV-2 proliferation by catalyzing the K29-typed ubiquitination of NP to enhance the ability to bind viral genomes.
    6. The disordered N-terminal tail of SARS-CoV-2 Nucleocapsid protein forms a dynamic complex with RNA.
      Title: The disordered N-terminal tail of SARS-CoV-2 Nucleocapsid protein forms a dynamic complex with RNA.
    7. The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation.
      Title: The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation.
    8. Assembly of SARS-CoV-2 ribonucleosomes by truncated N[ *] variant of the nucleocapsid protein.
      Title: Assembly of SARS-CoV-2 ribonucleosomes by truncated N(∗) variant of the nucleocapsid protein.
    9. Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex.
      Title: Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex.
    10. The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis.
      Title: The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (66)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

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    Preferred Names
    nucleocapsid phosphoprotein
    YP_009724397.2
    • ORF9; structural protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_045512.2 Reference assembly

      Range
      28274..29533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_009724397.2 nucleocapsid phosphoprotein [Severe acute respiratory syndrome coronavirus 2]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P0DTC9
      UniProtKB/TrEMBL
      A0A6B9VLF5, A0A6B9VNN9, A0A6C0N5E8, A0A6C0T6Z7, A0A6H0C6H8, A0A6H2L7M5, A0A6M3T200, A0A6M6CJY7, A0A6V7AMQ7, A0A6V7AN48, A0A7D5I3X2, A0A7D7P5S6, A0A7H0M5Q1, A0A7S6Z877, A0A8A7QML0
      Conserved Domains (1) summary
      pfam00937
      Location:40 → 388
      Corona_nucleoca; Coronavirus nucleocapsid protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DTC9.1 P0DTC9

    Gene LinkOut

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