U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    E envelope protein [ Severe acute respiratory syndrome coronavirus 2 ]

    Gene ID: 43740570, updated on 8-Sep-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    E
    Gene description
    envelope protein
    Locus tag
    GU280_gp04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Severe acute respiratory syndrome coronavirus 2 (isolate: Wuhan-Hu-1, nat-host: Homo sapiens)
    Lineage
    Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
    Summary
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ The structural proteins of SARS-CoV-2 include the envelope protein (E), spike or surface glycoprotein (S), membrane protein (M) and the nucleocapsid protein (N). The envelope protein is found in virus particles. This protein facilitates assembly and release of the virus and has ion channel activity required for pathogenesis.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_045512.2 (26245..26472)

    NC_045512.2Genomic Context describing neighboring genes Neighboring gene surface glycoprotein Neighboring gene ORF3a protein Neighboring gene membrane glycoprotein Neighboring gene ORF6 protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_045512.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Oligomerization-Dependent Beta-Structure Formation in SARS-CoV-2 Envelope Protein. Surya W, et al. Int J Mol Sci, 2022 Oct 31. PMID 36362071, Free PMC Article
    2. SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 Interventions. Planès R, et al. Viruses, 2022 May 8. PMID 35632741, Free PMC Article
    3. A SARS-CoV-2 variant with the 12-bp deletion at E gene. Sun YS, et al. Emerg Microbes Infect, 2020 Dec. PMID 33118859, Free PMC Article
    4. Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2. Alam I, et al. Front Cell Infect Microbiol, 2020. PMID 32850499, Free PMC Article
    5. Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers. Mandala VS, et al. Nat Struct Mol Biol, 2020 Dec. PMID 33177698, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A short sequence in the tail of SARS-CoV-2 envelope protein controls accessibility of its PDZ-binding motif to the cytoplasm.
      Title: A short sequence in the tail of SARS-CoV-2 envelope protein controls accessibility of its PDZ-binding motif to the cytoplasm.
    2. Atomic structure of the open SARS-CoV-2 E viroporin.
      Title: Atomic structure of the open SARS-CoV-2 E viroporin.
    3. The Cytoplasmic Domain of the SARS-CoV-2 Envelope Protein Assembles into a beta-Sheet Bundle in Lipid Bilayers.
      Title: The Cytoplasmic Domain of the SARS-CoV-2 Envelope Protein Assembles into a β-Sheet Bundle in Lipid Bilayers.
    4. SARS-CoV-2 Harnesses Host Translational Shutoff and Autophagy To Optimize Virus Yields: the Role of the Envelope (E) Protein.
      Title: SARS-CoV-2 Harnesses Host Translational Shutoff and Autophagy To Optimize Virus Yields: the Role of the Envelope (E) Protein.
    5. Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.
      Title: Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.
    6. SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 Interventions.
      Title: SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 Interventions.
    7. Structure and dynamics of the SARS-CoV-2 envelope protein monomer.
      Title: Structure and dynamics of the SARS-CoV-2 envelope protein monomer.
    8. Surface Proteins of SARS-CoV-2 Drive Airway Epithelial Cells to Induce IFN-Dependent Inflammation.
      Title: Surface Proteins of SARS-CoV-2 Drive Airway Epithelial Cells to Induce IFN-Dependent Inflammation.
    9. Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants.
      Title: Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants.
    10. TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines.
      Title: TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Go to the top of the page Help
    Preferred Names
    envelope protein
    YP_009724392.1
    • ORF4; structural protein; E protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_045512.2 Reference assembly

      Range
      26245..26472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_009724392.1 envelope protein [Severe acute respiratory syndrome coronavirus 2]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P0DTC4
      UniProtKB/TrEMBL
      A0A2R3SUY7, A0A6B9WFC7, A0A6C0QFP9, A0A6C0QFQ7, A0A6H0JNC3, A0A6H1PLD4, A0A6M4MLZ1, A0A6M4MVT6, A0A6N1NEQ8, A0A6N1VWC2, A0A6V7AL81, A0A6V7ALI4, A0A7D5I1K7, A0A7D5Y7V2, A0A7D6IRT7, A0A7D7G9Z4, A0A7L8MQ21, A0A7R6WEA1, A0A7T1CC84, A0A7T8H817, A0A7U2CKV5, A0A7U3EMI4, A0A883C1C2, A0A890DC26, A0A8A4Y2B6, A0A8B6RG68
      Conserved Domains (1) summary
      cd21536
      Location:2 → 75
      SARS-CoV-2_E; Severe acute respiratory syndrome coronavirus 2 Envelope small membrane protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DTC4.1 P0DTC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.