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    egr3 early growth response 3 [ Danio rerio (zebrafish) ]

    Gene ID: 436920, updated on 2-Nov-2024

    Summary

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    Official Symbol
    egr3provided by ZNC
    Official Full Name
    early growth response 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-394
    See related
    Ensembl:ENSDARG00000089156 AllianceGenome:ZFIN:ZDB-GENE-040718-394
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92020
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in hindbrain; myeloid cell; optic tectum; and telencephalon. Orthologous to human EGR3 (early growth response 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See egr3 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (50727220..50735559)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (50738574..50744862)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene rho-related BTB domain-containing protein 2-like Neighboring gene phosphatidylethanolamine binding protein 4 Neighboring gene uncharacterized LOC137496392 Neighboring gene bridging integrator 3 Neighboring gene acyl-CoA synthetase long chain family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis. da Silva AR, et al. Sci Adv, 2024 May 17. PMID 38748804, Free PMC Article
    2. A Structural Atlas of the Developing Zebrafish Telencephalon Based on Spatially-Restricted Transgene Expression. Turner KJ, et al. Front Neuroanat, 2022. PMID 35721460, Free PMC Article
    3. Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Fish JE, et al. Development, 2017 Jul 1. PMID 28536097, Free PMC Article
    4. Common and specific downstream signaling targets controlled by Tlr2 and Tlr5 innate immune signaling in zebrafish. Yang S, et al. BMC Genomics, 2015 Jul 25. PMID 26208853, Free PMC Article
    5. Iroquois Homeobox 1 Acts as a True Tumor Suppressor in Multiple Organs by Regulating Cell Cycle Progression. Jung IH, et al. Neoplasia, 2019 Oct. PMID 31450023, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis.
      Title: egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    early growth response protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002647.1 → NP_001002647.1  early growth response protein 3

      See identical proteins and their annotated locations for NP_001002647.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076527
      UniProtKB/TrEMBL
      Q6DG27
      Related
      ENSDARP00000109921.1, ENSDART00000127062.3
      Conserved Domains (4) summary
      COG5048
      Location:325 → 405
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:299 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam11928
      Location:88 → 158
      DUF3446; Domain of unknown function (DUF3446)
      pfam13465
      Location:341 → 366
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      50727220..50735559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222927.1 → XP_068079028.1  early growth response protein 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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