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    Cibar2 CBY1 interacting BAR domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 436062, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cibar2provided by MGI
    Official Full Name
    CBY1 interacting BAR domain containing 2provided by MGI
    Primary source
    MGI:MGI:3588213
    See related
    Ensembl:ENSMUSG00000042269 AllianceGenome:MGI:3588213
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam92b; 1700120B06Rik
    Summary
    Predicted to be involved in cilium assembly. Located in ciliary basal body. Is expressed in lung. Orthologous to human CIBAR2 (CBY1 interacting BAR domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in ovary adult (RPKM 3.7), lung adult (RPKM 3.1) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cibar2 in Genome Data Viewer
    Location:
    8 E1; 8 69.09 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120893136..120904225, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (120166397..120177486, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A130014A01 gene Neighboring gene RIKEN cDNA 6430548M08 gene Neighboring gene STARR-positive B cell enhancer ABC_E3811 Neighboring gene STARR-positive B cell enhancer mm9_chr8:122701278-122701579 Neighboring gene STARR-positive B cell enhancer ABC_E5046 Neighboring gene RIKEN cDNA A330074K22 gene Neighboring gene STARR-positive B cell enhancer ABC_E10527 Neighboring gene genetic suppressor element 1, coiled-coil protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122809115-122809356 Neighboring gene VISTA enhancer mm196 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122831174-122831375 Neighboring gene STARR-seq mESC enhancer starr_22881 Neighboring gene predicted gene, 32968

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis. Li FQ, et al. Mol Cell Biol, 2016 Nov 1. PMID 27528616, Free PMC Article
    2. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CBY1-interacting BAR domain-containing protein 2
    Names
    family with sequence similarity 92, member B
    protein FAM92B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033980.2 → NP_001029152.2  CBY1-interacting BAR domain-containing protein 2

      See identical proteins and their annotated locations for NP_001029152.2

      Status: VALIDATED

      Source sequence(s)
      AC163442, BC147233
      Consensus CDS
      CCDS22717.1
      UniProtKB/Swiss-Prot
      B2RVK4, Q3V2J0
      Related
      ENSMUSP00000038825.7, ENSMUST00000048786.13
      Conserved Domains (1) summary
      cd07598
      Location:6 → 216
      BAR_FAM92; The Bin/Amphiphysin/Rvs (BAR) domain of Family with sequence similarity 92 (FAM92)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      120893136..120904225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248434.1 → XP_011246736.1  CBY1-interacting BAR domain-containing protein 2 isoform X4

      Conserved Domains (1) summary
      cl12013
      Location:1 → 76
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_030243658.1 → XP_030099518.1  CBY1-interacting BAR domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      cl12013
      Location:8 → 80
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_011248429.1 → XP_011246731.1  CBY1-interacting BAR domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011246731.1

      Conserved Domains (1) summary
      cd07598
      Location:6 → 216
      BAR_FAM92; The Bin/Amphiphysin/Rvs (BAR) domain of Family with sequence similarity 92 (FAM92)

    4. XM_011248431.1 → XP_011246733.1  CBY1-interacting BAR domain-containing protein 2 isoform X2

      Conserved Domains (1) summary
      cd07598
      Location:1 → 203
      BAR_FAM92; The Bin/Amphiphysin/Rvs (BAR) domain of Family with sequence similarity 92 (FAM92)

    5. XM_030243659.1 → XP_030099519.1  CBY1-interacting BAR domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      cl12013
      Location:8 → 80
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V2J0.2 GenPept UniProtKB/Swiss-Prot:Q3V2J0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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