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    Hrb98DE Heterogeneous nuclear ribonucleoprotein at 98DE [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43385, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Hrb98DEprovided by FlyBase
    Official Full Name
    Heterogeneous nuclear ribonucleoprotein at 98DEprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001215
    Locus tag
    Dmel_CG9983
    See related
    AllianceGenome:FB:FBgn0001215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-E7Delta6; CG9983; Dmel\CG9983; E7Delta6; HDP(P9); hnRNP A2/B1; Hrb1; hrb98 de; Hrb98 de; hrb98de; hrb98DE; HRB98DE; Hrb98DE/Hrp38; HRB98DE/hrp38; hrp38; Hrp38; p9; Pen9
    Summary
    Enables mRNA 5'-UTR binding activity and sequence-specific DNA binding activity. Involved in several processes, including female germ-line stem cell population maintenance; positive regulation of translation; and regulation of RNA splicing. Located in nucleus and polytene chromosome puff. Part of ribonucleoprotein complex. Is expressed in several structures, including adult head; central nervous system; extended germ band embryo; and gonad. Used to study myopathy and neurodegenerative disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; inclusion body myopathy with Paget disease of bone and frontotemporal dementia; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3; and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See Hrb98DE in Genome Data Viewer
    Location:
    98D6-98D6; 3-96 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28599834..28605777)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24425556..24431499)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43440 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Noa36 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Hrb98DE locus encodes four protein isoforms homologous to the A1 protein of mammalian heterogeneous nuclear ribonucleoprotein complexes. Haynes SR, et al. Mol Cell Biol, 1990 Jan. PMID 2104660, Free PMC Article
    2. The Drosophila Hrb87F gene encodes a new member of the A and B hnRNP protein group. Haynes SR, et al. Nucleic Acids Res, 1991 Jan 11. PMID 1849257, Free PMC Article
    3. Heterogeneous nuclear ribonucleoprotein complexes and proteins in Drosophila melanogaster. Raychaudhuri G, et al. Mol Cell Biol, 1992 Feb. PMID 1732749, Free PMC Article
    4. Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription. Amero SA, et al. Proc Natl Acad Sci U S A, 1992 Sep 15. PMID 1388268, Free PMC Article
    5. Genetic variation in P-element dysgenic sterility is associated with double-strand break repair and alternative splicing of TE transcripts. Lama J, et al. PLoS Genet, 2022 Dec. PMID 36477699, Free PMC Article

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables poly(G) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in female germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome puff IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein at 98DE
    Names
    CG9983-PA
    CG9983-PB
    CG9983-PC
    CG9983-PD
    CG9983-PE
    CG9983-PF
    Hrb98DE-PA
    Hrb98DE-PB
    Hrb98DE-PC
    Hrb98DE-PD
    Hrb98DE-PE
    Hrb98DE-PF
    hnRNA-binding protein 1
    s

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28599834..28605777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170370.2 → NP_733249.1  heterogeneous nuclear ribonucleoprotein at 98DE, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733249.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH29
      Related
      FBpp0084667
      Conserved Domains (2) summary
      cd12578
      Location:31 → 108
      RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:122 → 194
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_170371.2 → NP_733250.1  heterogeneous nuclear ribonucleoprotein at 98DE, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733250.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV67, E8NH29
      Related
      FBpp0084668
      Conserved Domains (2) summary
      cd12578
      Location:27 → 104
      RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:118 → 190
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_079819.3 → NP_524543.1  heterogeneous nuclear ribonucleoprotein at 98DE, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524543.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P07909, Q24359, Q24360, Q99361, Q9VAU7, Q9VAU8
      UniProtKB/TrEMBL
      A4V3J5, E6PBW8
      Related
      FBpp0084669
      Conserved Domains (2) summary
      cd12578
      Location:32 → 109
      RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:123 → 195
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_170374.2 → NP_733253.1  heterogeneous nuclear ribonucleoprotein at 98DE, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733253.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V3J6, E6PBW8
      Related
      FBpp0084672
      Conserved Domains (2) summary
      cd12578
      Location:28 → 105
      RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:119 → 191
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. NM_170372.2 → NP_733251.1  heterogeneous nuclear ribonucleoprotein at 98DE, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733251.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P07909, Q24359, Q24360, Q99361, Q9VAU7, Q9VAU8
      UniProtKB/TrEMBL
      A4V3J5, E6PBW8
      Related
      FBpp0084670
      Conserved Domains (2) summary
      cd12578
      Location:32 → 109
      RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:123 → 195
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. NM_170373.2 → NP_733252.1  heterogeneous nuclear ribonucleoprotein at 98DE, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733252.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V3J6, E6PBW8
      Related
      FBpp0084671
      Conserved Domains (2) summary
      cd12578
      Location:28 → 105
      RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:119 → 191
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V3J5 A4V3J5
    A4V3J6 A4V3J6
    P07909.1 P07909

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