MELTF melanotransferrin [Homo sapiens (human)] - Gene

Summary

Official Symbol: MELTFprovided by HGNC
Official Full Name: melanotransferrinprovided by HGNC
Primary source: HGNC:HGNC:7037
See related: Ensembl:ENSG00000163975 MIM:155750; AllianceGenome:HGNC:7037
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MTf; MFI2; MTF1; CD228; MAP97
Summary: The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]
Expression: Broad expression in salivary gland (RPKM 9.5), kidney (RPKM 5.4) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q29

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (197001740..197029817, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (199727923..199756006, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (196728611..196756688, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterizing ATP processing by the AAA+ protein p97 at the atomic level.
Title: Characterizing ATP processing by the AAA+ protein p97 at the atomic level.
The E2F1/MELTF axis fosters the progression of lung adenocarcinoma by regulating the Notch signaling pathway.
Title: The E2F1/MELTF axis fosters the progression of lung adenocarcinoma by regulating the Notch signaling pathway.
MELTF Might Regulate Ferroptosis, Pyroptosis, and Autophagy in Platelet-Rich Plasma-Mediated Endometrial Epithelium Regeneration.
Title: MELTF Might Regulate Ferroptosis, Pyroptosis, and Autophagy in Platelet-Rich Plasma-Mediated Endometrial Epithelium Regeneration.
The Role of Melanotransferrin (CD228) in the regulation of the differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells (hBM-MSC).
Title: The Role of Melanotransferrin (CD228) in the regulation of the differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells (hBM-MSC).
The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke.
Title: The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke.
High MELTF mRNA expression was associated with Gastric Cancer.
Title: Level of Melanotransferrin in Tissue and Sera Serves as a Prognostic Marker of Gastric Cancer.
Melanotransferrin is a serological marker of colorectal cancer by secretome analysis and quantitative proteomics.
Title: Discovery of melanotransferrin as a serological marker of colorectal cancer by secretome analysis and quantitative proteomics.
PC3 tumors are sustained by a small number of tumor-initiating cells with stem-like characteristics, including strong self-renewal and pro-angiogenic capability and marked by the expression pattern FAM65Bhigh/MFI2low/LEF1low.
Title: PC3 prostate tumor-initiating cells with molecular profile FAM65Bhigh/MFI2low/LEF1low increase tumor angiogenesis.
Biochemical and spectroscopic studies of MTF1 are reported.
Title: Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins.
Novel molecular targets directly or indirectly regulated by MTf and the potential pathways involved in its function, including modulation of proliferation.
Title: Identification of distinct changes in gene expression after modulation of melanoma tumor antigen p97 (melanotransferrin) in multiple models in vitro and in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of MELTF	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:181216 (e-PCR)
- UniSTS:155184

D1S3690 (e-PCR)
- UniSTS:474268

RH102338 (e-PCR)
- UniSTS:96672

NoName (e-PCR)
- UniSTS:483264

NoName (e-PCR)
- UniSTS:490436

STS-M12154 (e-PCR)
- UniSTS:33483

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables iron ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in iron ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of extracellular matrix disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of plasminogen activation	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: melanotransferrin

Names: antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5; membrane-bound transferrin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005929.6 → NP_005920.2 melanotransferrin isoform 1 preproprotein

See identical proteins and their annotated locations for NP_005920.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1), as compared to variant 2.

Source sequence(s)

AA442552, AC068302, AH002920, BQ447289

Consensus CDS

CCDS3325.1

UniProtKB/Swiss-Prot

P08582, Q9BQE2

UniProtKB/TrEMBL

A0A8Q3WLY9

Related

ENSP00000296350.5, ENST00000296350.10

Conserved Domains (2) summary

smart00094
Location:367 → 706

TR_FER; Transferrin

pfam00405
Location:23 → 357

Transferrin
NM_033316.4 → NP_201573.1 melanotransferrin isoform 2 precursor

See identical proteins and their annotated locations for NP_201573.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs from variant 1 in the central coding region, resulting in a frameshift. The encoded isoform (2) has a truncated and distinct C-terminus and lacks the propeptide compared to isoform 1.

Source sequence(s)

AC068302, AU099352, BC071910

Consensus CDS

CCDS3326.1

UniProtKB/TrEMBL

Q53XS6

Related

ENSP00000296351.4, ENST00000296351.8

Conserved Domains (1) summary

cl26270
Location:23 → 301

Transferrin; Transferrin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

197001740..197029817 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047448150.1 → XP_047304106.1 melanotransferrin isoform X3
XM_006713643.4 → XP_006713706.2 melanotransferrin isoform X2

Conserved Domains (4) summary

smart00094
Location:367 → 732

TR_FER; Transferrin

cd13529
Location:23 → 355

PBP2_transferrin; Transferrin family of the type 2 periplasmic-binding protein superfamily

pfam00405
Location:23 → 357

Transferrin; Transferrin

cl21456
Location:367 → 727

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_011512850.3 → XP_011511152.1 melanotransferrin isoform X1

Conserved Domains (3) summary

smart00094
Location:367 → 733

TR_FER; Transferrin

cd13529
Location:23 → 355

PBP2_transferrin; Transferrin family of the type 2 periplasmic-binding protein superfamily

pfam00405
Location:23 → 357

Transferrin; Transferrin