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    HSF1 heat shock transcription factor 1 [ Gallus gallus (chicken) ]

    Gene ID: 420362, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HSF1provided by CGNC
    Official Full Name
    heat shock transcription factor 1provided by CGNC
    Primary source
    CGNC:51234
    See related
    Ensembl:ENSGALG00010009352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    HSF 1; HSF 3A; HSTF 1; HSTF 3A
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See HSF1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (148261326..148358452, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (148987448..149072486)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121113091 Neighboring gene uncharacterized LOC121113105 Neighboring gene VPS28 subunit of ESCRT-I Neighboring gene uncharacterized LOC121113106 Neighboring gene uncharacterized LOC112531891 Neighboring gene block of proliferation 1 Neighboring gene maestro heat-like repeat-containing protein family member 1-like Neighboring gene scleraxis bHLH transcription factor Neighboring gene uncharacterized LOC107049554

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Co-enzyme Q10 protects chicken hearts from in vivo heat stress via inducing HSF1 binding activity and Hsp70 expression. Xu J, et al. Poult Sci, 2019 Feb 1. PMID 30339219
    2. Effect of dietary manganese on antioxidant status and expressions of heat shock proteins and factors in tissues of laying broiler breeders under normal and high environmental temperatures. Zhu YW, et al. Br J Nutr, 2016 Dec. PMID 27890044
    3. Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway. Nakai A, et al. Mol Cell Biol, 1993 Apr. PMID 8455593, Free PMC Article
    4. Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1, and heat shock factor pathways. Hatori M, et al. Proc Natl Acad Sci U S A, 2011 Mar 22. PMID 21383147, Free PMC Article
    5. Cell cycle transition under stress conditions controlled by vertebrate heat shock factors. Nakai A, et al. EMBO J, 2001 Jun 1. PMID 11387221, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Co-enzyme Q10 can protect chicken hearts from in vivo heat stress by inducing HSF1 binding activity and Hsp70 expression.
      Title: Co-enzyme Q10 protects chicken hearts from in vivo heat stress via inducing HSF1 binding activity and Hsp70 expression.
    2. Data suggest that exposure to high environmental temperature up-regulates expression of heat shock factor 1 (HSF1) mRNA, HSF3 mRNA, and heat shock protein 70 (HSP70) mRNA/protein in liver, heart, and breast muscle; dietary supplementation with manganese down-regulates expression of HSP70 in breast muscle.
      Title: Effect of dietary manganese on antioxidant status and expressions of heat shock proteins and factors in tissues of laying broiler breeders under normal and high environmental temperatures.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heat shock factor protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305256.1 → NP_001292185.1  heat shock factor protein 1

      See identical proteins and their annotated locations for NP_001292185.1

      Status: VALIDATED

      Source sequence(s)
      L06098
      UniProtKB/Swiss-Prot
      I7GGU6, P38529
      Related
      ENSGALP00010012808.1, ENSGALT00010022280.1
      Conserved Domains (2) summary
      smart00415
      Location:19 → 123
      HSF; heat shock factor
      pfam06546
      Location:252 → 491
      Vert_HS_TF; Vertebrate heat shock transcription factor

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      148261326..148358452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      148987448..149072486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38529.1 GenPept UniProtKB/Swiss-Prot:P38529

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials