kibra kibra [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: kibraprovided by FlyBase
Official Full Name: kibraprovided by FlyBase
Primary source: FLYBASE:FBgn0262127
Locus tag: Dmel_CG33967
See related: AllianceGenome:FB:FBgn0262127
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12600; CG33967; CG7552; Dmel\CG33967; DmKibra; kbr; Kbr; kib; Kib; Kibra; l(3)02404; l(3)j5C3; l(3)neo42; ORE-2; RE26350; WWC1
Summary: Predicted to enable kinase binding activity and molecular adaptor activity. Involved in several processes, including R8 cell differentiation; border follicle cell migration; and positive regulation of hippo signaling. Located in apicomedial cortex and cytoplasmic side of apical plasma membrane. Part of Kibra-Ex-Mer complex. Is active in apical cortex. Colocalizes with cell-cell junction. Is expressed in border follicle cell; embryonic/larval epidermis; epidermal cell; follicle cell; and wing disc. Orthologous to several human genes including WWC1 (WW and C2 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 88D1-88D1; 3-56 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14697689..14724261, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (10523411..10549983, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling.
Title: Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling.
Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription.
Title: Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription.
elevated expression of Par3 promotes PCa metastasis via KIBRA sequestration-mediated inactivation of the Hippo pathway to upregulate expression of pro-metastatic genes.
Title: Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway.
Merlin and Kibra activate Hippo signaling in parallel to Expanded at a spatially distinct cellular domain, the medial apical cortex.
Title: Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded.
Kibra, a binding partner of Pez, stabilizes Pez via WW-PY/PPxY interaction.
Title: Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis.
Kibra regulates starvation-induced autophagy downstream of aPKC.
Title: Kibra and aPKC regulate starvation-induced autophagy in Drosophila.
In the human brain, KIBRA is mainly expressed in hippocampus and interacts with proteins involved in long-term potentiation and synaptic plasticity and effect memory in aged.
Title: Genetics and functional imaging: effects of APOE, BDNF, COMT, and KIBRA in aging.
The result reveals role for Kibra in neuronal specification and maintenance and show that the Hippo pathway is reimplemented for sensory neuron fate by combining canonical and noncanonical regulatory steps.
Title: Binary regulation of Hippo pathway by Merlin/NF2, Kibra, Lgl, and Melted specifies and maintains postmitotic neuronal fate.
Kibra predominantly acts in the Merlin branch upstream of the core kinase cascade to regulate Hippo signaling.
Title: The WW domain protein Kibra acts upstream of Hippo in Drosophila.
Kibra is a regulator of the Salvador/Warts/Hippo signaling network.
Title: Kibra is a regulator of the Salvador/Warts/Hippo signaling network.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c14707050-14706982 mobile_element_type = transposon:INE-1{}4043

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in R8 cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in R8 cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of organ growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Kibra-Ex-Mer complex	IDA Inferred from Direct Assay more info	PubMed
part_of Kibra-Ex-Mer complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in apicomedial cortex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kibra

Names: CG33967-PA; CG33967-PB; kibra ortholog; kibra-PA; kibra-PB; lethal (3) neo42

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

14697689..14724261 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300400.1 → NP_001287329.1 kibra, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287329.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5BIC8, Q9VFG8

UniProtKB/TrEMBL

A0A0B4LH59

Conserved Domains (3) summary

cd08680
Location:693 → 813

C2_Kibra; C2 domain found in Human protein Kibra

cd00201
Location:57 → 87

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:103 → 132

WW; WW domain
NM_001038966.2 → NP_001034055.1 kibra, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001034055.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5BIC8, Q9VFG8

UniProtKB/TrEMBL

A0A0B4LH59

Conserved Domains (3) summary

cd08680
Location:693 → 813

C2_Kibra; C2 domain found in Human protein Kibra

cd00201
Location:57 → 87

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:103 → 132

WW; WW domain