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    SPINK7 serine peptidase inhibitor, Kazal type 7 (putative) [ Gallus gallus (chicken) ]

    Gene ID: 416236, updated on 19-Sep-2023

    Summary

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    Official Symbol
    SPINK7provided by CGNC
    Official Full Name
    serine peptidase inhibitor, Kazal type 7 (putative)provided by CGNC
    Primary source
    CGNC:50205
    See related
    Ensembl:ENSGALG00010014724
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    OM; OVM; SPIK7
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    Genomic context

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    See SPINK7 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 13 NC_052544.1 (10179106..10184657)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 13 NC_052585.1 (10181359..10186934)

    Chromosome 13 - NC_052544.1Genomic Context describing neighboring genes Neighboring gene serine protease inhibitor Kazal-type 5-like Neighboring gene uncharacterized LOC101749216 Neighboring gene serine peptidase inhibitor, Kazal type 5 Neighboring gene ovoinhibitor-like Neighboring gene serine protease inhibitor Kazal-type 6-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thermodynamic analyses of the constitutive splicing pathway for ovomucoid pre-mRNA. Ro-Choi TS, et al. Mol Cells, 2009 Jun 30. PMID 19533036
    2. Linkage mapping of chicken ovoinhibitor and ovomucoid genes to chromosome 13. Kinoshita K, et al. Anim Genet, 2004 Aug. PMID 15265086
    3. Identification and fine mapping of IgG and IgE epitopes in ovomucoid. Mine Y, et al. Biochem Biophys Res Commun, 2002 Apr 12. PMID 11944924
    4. Primary sequence of ovomucoid messenger RNA as determined from cloned complementary DNA. Catterall JF, et al. J Cell Biol, 1980 Nov. PMID 7430252, Free PMC Article
    5. Androgens regulate ovomucoid and ovalbumin gene expression independently of estrogen. Compere SJ, et al. J Biol Chem, 1981 Jun 25. PMID 7240208

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that both ovalbumin and ovomucoid were efficiently mutagenized in cultured primordial germ cells (PGCs) by CRISPR/Cas9 system.
      Title: Targeted mutagenesis in chicken using CRISPR/Cas9 system.
    2. turtle-dove (Streptopelia risoria) ovomucoid is differentiated from chicken ovomucoid as it inhibits both trypsin and chymotrypsin to some extent; chick ovomucoid has no effect on chymotrypsin, but completely inhibits trypsin.
      Title: Turtle-dove ovomucoid, a glycoprotein proteinase inhibitor with P1-blood-group antigen activity.
    3. estrogen & steroid hormones work in synergy to increase ovomucoid mRNA synthesis and accumulation in the oviduct; steroid hormones also act independently of estrogen to restimulate transcription of the ovalbumin and ovomucoid genes
      Title: Androgens regulate ovomucoid and ovalbumin gene expression independently of estrogen.
    4. demonstrate that ovomuccoid mRNA has a 24 aa leader sequence and that ovomuccoid but not pre-ovomuccoid has trypsin inhibition activity
      Title: Precursor of egg white ovomucoid. Amino acid sequence of an NH2-terminal extension.
    5. The preferred order of intron removals can be described by a consideration of free energy changes involved in the spliceosomal assembly pathway.
      Title: Thermodynamic analyses of the constitutive splicing pathway for ovomucoid pre-mRNA.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ovomucoid
    Names
    allergen Gal d 1
    allergen Gal d I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112662.2 → NP_001106132.1  ovomucoid isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      JAENSK010000256
      UniProtKB/TrEMBL
      B6V1G0
      Conserved Domains (2) summary
      cd01327
      Location:42 → 86
      KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...
      pfam00050
      Location:108 → 151
      Kazal_1; Kazal-type serine protease inhibitor domain

    2. NM_001308494.2 → NP_001295423.1  ovomucoid isoform 1 precursor

      See identical proteins and their annotated locations for NP_001295423.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAENSK010000256
      UniProtKB/Swiss-Prot
      P01005
      UniProtKB/TrEMBL
      B6V1G0
      Related
      ENSGALP00010020595.1, ENSGALT00010035385.1
      Conserved Domains (2) summary
      cd01327
      Location:42 → 86
      KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...
      pfam00050
      Location:108 → 151
      Kazal_1; Kazal-type serine protease inhibitor domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      10179106..10184657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      10181359..10186934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01005.1 GenPept UniProtKB/Swiss-Prot:P01005

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials