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    Octbeta2R Octopamine beta2 receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41549, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Octbeta2Rprovided by FlyBase
    Official Full Name
    Octopamine beta2 receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038063
    Locus tag
    Dmel_CG33976
    See related
    AllianceGenome:FB:FBgn0038063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.184; anon-WO0170980.185; CG18553; CG33976; CG6989; DmCG6989; Dmel\CG33976; DmOctbeta2R; Dm_3R:45121; octb2R; Octb2R; OctB2R; Octbeta-like; OctBeta2; octbeta2r; octbeta2R; Octbeta2r; OCTbeta2R
    Summary
    Enables octopamine receptor activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; ovulation; and positive regulation of synaptic assembly at neuromuscular junction. Is integral component of plasma membrane. Is expressed in several structures, including adult muscle system; central nervous system; epithelial tube; gut section; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); disease of metabolism (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Orthologous to several human genes including HTR4 (5-hydroxytryptamine receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Octbeta2R in Genome Data Viewer
    Location:
    87C1-87C2; 3-52 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12550625..12595725, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8376347..8421447, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Octopamine beta3 receptor Neighboring gene long non-coding RNA:CR46016 Neighboring gene Hugin Neighboring gene mir-284 stem loop Neighboring gene long non-coding RNA:CR46017 Neighboring gene long non-coding RNA:CR44942

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maintenance of quiescent oocytes by noradrenergic signals. Kim J, et al. Nat Commun, 2021 Nov 26. PMID 34836956, Free PMC Article
    2. Expression of β-adrenergic-like octopamine receptors during Drosophila development. Ohhara Y, et al. Zoolog Sci, 2012 Feb. PMID 22303848
    3. Octopamine signaling via OctαR is essential for a well-orchestrated climbing performance of adult Drosophila melanogaster. El-Kholy SE, et al. Sci Rep, 2022 Aug 18. PMID 35982189, Free PMC Article
    4. A Model for Basic Emotions Using Observations of Behavior in Drosophila. Gu S, et al. Front Psychol, 2019. PMID 31068849, Free PMC Article
    5. Genetic and Neurobiological Analyses of the Noradrenergic-like System in Vulnerability to Sugar Overconsumption Using a Drosophila Model. Branch A, et al. Sci Rep, 2017 Dec 15. PMID 29247240, Free PMC Article

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled amine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables octopamine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables octopamine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables octopamine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ovulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    octopamine beta2 receptor
    Names
    CG33976-PA
    CG33976-PC
    CG33976-PD
    CG33976-PE
    CG33976-PF
    CG33976-PG
    OctBeta2R
    Octbeta2R-PA
    Octbeta2R-PC
    Octbeta2R-PD
    Octbeta2R-PE
    Octbeta2R-PF
    Octbeta2R-PG
    octopamine beta receptor
    octopamine receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12550625..12595725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316576.1 → NP_001303505.1  octopamine beta2 receptor, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7FNM5, Q4LBB9, Q9VG53, Q9VG54
      UniProtKB/TrEMBL
      A0A126GUT9
      Conserved Domains (2) summary
      pfam00001
      Location:170 → 465
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:164 → 342
      7tm_4; Olfactory receptor

    2. NM_001260149.2 → NP_001247078.1  octopamine beta2 receptor, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247078.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7FNM5, Q4LBB9, Q9VG53, Q9VG54
      UniProtKB/TrEMBL
      A0A126GUT9
      Conserved Domains (2) summary
      pfam00001
      Location:170 → 465
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:164 → 342
      7tm_4; Olfactory receptor

    3. NM_001260148.1 → NP_001247077.1  octopamine beta2 receptor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247077.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7FNM5, Q4LBB9, Q9VG53, Q9VG54
      UniProtKB/TrEMBL
      A0A126GUT9
      Conserved Domains (2) summary
      pfam00001
      Location:170 → 465
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:164 → 342
      7tm_4; Olfactory receptor

    4. NM_001260147.1 → NP_001247076.1  octopamine beta2 receptor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247076.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7FNM5, Q4LBB9, Q9VG53, Q9VG54
      UniProtKB/TrEMBL
      A0A126GUT9
      Conserved Domains (2) summary
      pfam00001
      Location:170 → 465
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:164 → 342
      7tm_4; Olfactory receptor

    5. NM_001038960.3 → NP_001034049.1  octopamine beta2 receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034049.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7FNM5, Q4LBB9, Q9VG53, Q9VG54
      UniProtKB/TrEMBL
      A0A126GUT9
      Conserved Domains (2) summary
      pfam00001
      Location:170 → 465
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:164 → 342
      7tm_4; Olfactory receptor

    6. NM_001170125.3 → NP_001163596.2  octopamine beta2 receptor, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163596.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIJ4
      Conserved Domains (2) summary
      pfam00001
      Location:170 → 465
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:164 → 342
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A126GUT9 A0A126GUT9
    E1JIJ4 E1JIJ4
    Q4LBB9.2 Q4LBB9

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