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    Prss57 serine protease 57 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 408241, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Prss57provided by RGD
    Official Full Name
    serine protease 57provided by RGD
    Primary source
    RGD:1303330
    See related
    EnsemblRapid:ENSRNOG00000025293 AllianceGenome:RGD:1303330
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Df2; NSP4; Prssl1
    Summary
    Predicted to enable heparin binding activity and serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in azurophil granule lumen and extracellular space. Orthologous to human PRSS57 (serine protease 57). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 1.9), Uterus (RPKM 0.5) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prss57 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10563477..10573617)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9915667..9922996)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12798310..12804668)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479814 Neighboring gene mitotic spindle positioning Neighboring gene paralemmin Neighboring gene follistatin like 3 Neighboring gene ring finger protein 126

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structures of neutrophil serine protease 4 reveal an unusual mechanism of substrate recognition by a trypsin-fold protease. Lin SJ, et al. Structure, 2014 Sep 2. PMID 25156428
    2. NSP4 is stored in azurophil granules and released by activated neutrophils as active endoprotease with restricted specificity. Perera NC, et al. J Immunol, 2013 Sep 1. PMID 23904161
    3. NSP4, an elastase-related protease in human neutrophils with arginine specificity. Perera NC, et al. Proc Natl Acad Sci U S A, 2012 Apr 17. PMID 22474388, Free PMC Article
    4. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in azurophil granule lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in azurophil granule lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    serine protease 57
    Names
    PRSSL1 homolog
    complement factor D-like protein
    neutrophil serine protease 4
    protease, serine, 57
    protease, serine-like 1
    serine protease 1-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003956.2 → NP_001003956.1  serine protease 57 precursor

      See identical proteins and their annotated locations for NP_001003956.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6K8X3, A6K8X4
      Conserved Domains (2) summary
      smart00020
      Location:33 → 203
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:34 → 214
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10563477..10573617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079725.2 → XP_038935653.1  serine protease 57 isoform X5

      Conserved Domains (1) summary
      cd00190
      Location:46 → 182
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. XM_039079723.2 → XP_038935651.1  serine protease 57 isoform X3

      UniProtKB/TrEMBL
      A6K8X3
      Conserved Domains (1) summary
      cd00190
      Location:46 → 234
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. XM_039079718.2 → XP_038935646.1  serine protease 57 isoform X1

      UniProtKB/TrEMBL
      A0A8L2UKW0
      Conserved Domains (1) summary
      cd00190
      Location:46 → 270
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    4. XM_063264091.1 → XP_063120161.1  serine protease 57 isoform X1

      UniProtKB/TrEMBL
      A0A8L2UKW0

    5. XM_063264089.1 → XP_063120159.1  serine protease 57 isoform X1

      UniProtKB/TrEMBL
      A0A8L2UKW0

    6. XM_039079716.2 → XP_038935644.1  serine protease 57 isoform X1

      UniProtKB/TrEMBL
      A0A8L2UKW0
      Conserved Domains (1) summary
      cd00190
      Location:46 → 270
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    7. XM_063264092.1 → XP_063120162.1  serine protease 57 isoform X2

      UniProtKB/Swiss-Prot
      Q6IE59
      UniProtKB/TrEMBL
      A0A8L2UKW0

    8. XM_006240979.5 → XP_006241041.1  serine protease 57 isoform X2

      See identical proteins and their annotated locations for XP_006241041.1

      UniProtKB/Swiss-Prot
      Q6IE59
      UniProtKB/TrEMBL
      A0A8L2UKW0
      Related
      ENSRNOP00000031690.5, ENSRNOT00000038553.5
      Conserved Domains (1) summary
      cd00190
      Location:34 → 258
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    9. XM_039079724.2 → XP_038935652.1  serine protease 57 isoform X4

      UniProtKB/TrEMBL
      A0A8L2UKW0
      Conserved Domains (1) summary
      cd00190
      Location:1 → 211
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IE59.2 GenPept UniProtKB/Swiss-Prot:Q6IE59

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