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    Btla B and T lymphocyte associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 407756, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Btlaprovided by RGD
    Official Full Name
    B and T lymphocyte associatedprovided by RGD
    Primary source
    RGD:1303280
    See related
    EnsemblRapid:ENSRNOG00000030246 AllianceGenome:RGD:1303280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in immune response-regulating cell surface receptor signaling pathway. Predicted to act upstream of or within cell surface receptor signaling pathway; negative regulation of B cell proliferation; and negative regulation of alpha-beta T cell proliferation. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human BTLA (B and T lymphocyte associated). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 252.8), Thymus (RPKM 79.8) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Btla in Genome Data Viewer
    Location:
    11q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (69069734..69099331, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (55563683..55588187, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (60523692..60547234, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene CD200 molecule like 1 Neighboring gene Cd200 molecule Neighboring gene phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase, pseudogene 6 Neighboring gene autophagy related 3 Neighboring gene solute carrier family 35, member A5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Combined Immunotherapy With Belatacept and BTLA Overexpression Attenuates Acute Rejection Following Kidney Transplantation. Zhang H, et al. Front Immunol, 2021. PMID 33732243, Free PMC Article
    2. B7x: a widely expressed B7 family member that inhibits T cell activation. Zang X, et al. Proc Natl Acad Sci U S A, 2003 Sep 2. PMID 12920180, Free PMC Article
    3. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Watanabe N, et al. Nat Immunol, 2003 Jul. PMID 12796776
    4. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Sedy JR, et al. Nat Immunol, 2005 Jan. PMID 15568026
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Combined Immunotherapy With Belatacept and BTLA Overexpression Attenuates Acute Rejection Following Kidney Transplantation.
      Title: Combined Immunotherapy With Belatacept and BTLA Overexpression Attenuates Acute Rejection Following Kidney Transplantation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response-regulating cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response-regulating cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune response-regulating cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    B- and T-lymphocyte attenuator
    Names
    B- and T-lymphocyte-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213630.2 → NP_998795.2  B- and T-lymphocyte attenuator precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q569B2, Q6PNM1
      UniProtKB/TrEMBL
      A0A1W2Q6H3
      Related
      ENSRNOP00000076251.2, ENSRNOT00000093151.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      69069734..69099331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248341.5 → XP_006248403.1  B- and T-lymphocyte attenuator isoform X1

      See identical proteins and their annotated locations for XP_006248403.1

      UniProtKB/Swiss-Prot
      Q569B2, Q6PNM1
      UniProtKB/TrEMBL
      A6IQZ1
      Conserved Domains (2) summary
      cd00096
      Location:61 → 139
      Ig; Immunoglobulin domain
      smart00410
      Location:50 → 142
      IG_like; Immunoglobulin like

    2. XM_063270686.1 → XP_063126756.1  B- and T-lymphocyte attenuator isoform X3

    3. XM_063270685.1 → XP_063126755.1  B- and T-lymphocyte attenuator isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PNM1.1 GenPept UniProtKB/Swiss-Prot:Q6PNM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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