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    ITGAM integrin subunit alpha M [ Bos taurus (domestic cattle) ]

    Gene ID: 407124, updated on 10-Oct-2024

    Summary

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    Official Symbol
    ITGAMprovided by VGNC
    Official Full Name
    integrin subunit alpha Mprovided by VGNC
    Primary source
    VGNC:VGNC:55056
    See related
    Ensembl:ENSBTAG00000047238
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CD11B
    Orthologs
    human mouse all
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    Genomic context

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    See ITGAM in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (27344045..27382746)

    Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene PYD and CARD domain containing Neighboring gene tripartite motif containing 72 Neighboring gene integrin alpha-X Neighboring gene large ribosomal subunit protein uL24-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction of reactive oxygen species in bovine neutrophils is CD11b, but not dectin-1-dependent. Conejeros I, et al. Vet Immunol Immunopathol, 2011 Feb 15. PMID 21106254
    2. Molecular cloning and characterization of cDNA encoding CD11b of cattle. Gopinath RS, et al. Vet Immunol Immunopathol, 2006 Apr 15. PMID 16476490
    3. Specific integrin subunits in bovine oocytes, including novel sequences for alpha 6 and beta 3 subunits. Pate BJ, et al. Mol Reprod Dev, 2007 May. PMID 17039534
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrin alpha-M
    Names
    integrin alpha M
    integrin, alpha M (complement component 3 receptor 3 subunit)
    leukocyte integrin alpha-M chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039957.1 → NP_001035046.1  integrin alpha-M precursor

      See identical proteins and their annotated locations for NP_001035046.1

      Status: PROVISIONAL

      Source sequence(s)
      AY841169
      UniProtKB/TrEMBL
      A0AAA9TSI5, Q24LN2
      Related
      ENSBTAP00000054571.1, ENSBTAT00000063617.3
      Conserved Domains (4) summary
      smart00191
      Location:516 → 571
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149 → 324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1129 → 1143
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:614 → 925
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27344045..27382746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059881165.1 → XP_059737148.1  integrin alpha-M isoform X1

      Related
      ENSBTAP00000100315.1, ENSBTAT00000117982.1

    2. XM_059881166.1 → XP_059737149.1  integrin alpha-M isoform X2

      UniProtKB/TrEMBL
      A0A3Q1NCI2
      Related
      ENSBTAP00000069105.1, ENSBTAT00000076414.2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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