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    rhoaa ras homolog gene family, member Aa [ Danio rerio (zebrafish) ]

    Gene ID: 406411, updated on 28-Oct-2024

    Summary

    Official Symbol
    rhoaaprovided by ZNC
    Official Full Name
    ras homolog gene family, member Aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2150
    See related
    Ensembl:ENSDARG00000026845 AllianceGenome:ZFIN:ZDB-GENE-040426-2150
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Rhoa; zgc:66058; zgc:85805; wu:fa66g04; wu:fb26g07
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including actin filament organization; skeletal muscle satellite cell migration; and wound healing, spreading of cells. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

    See rhoaa in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (14170571..14179798, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (14132866..14142093, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene biglycan a Neighboring gene si:dkey-6n6.1 Neighboring gene thiamin pyrophosphokinase 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B11 Neighboring gene DEF6 guanine nucleotide exchange factor a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in skeletal muscle satellite cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in wound healing, spreading of cells ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho-related GTP-binding protein RhoA-A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213137.1NP_998302.1  rho-related GTP-binding protein RhoA-A

      See identical proteins and their annotated locations for NP_998302.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056556
      UniProtKB/Swiss-Prot
      Q6NUX8
      Related
      ENSDARP00000040644.6, ENSDART00000040645.8
      Conserved Domains (2) summary
      smart00174
      Location:8181
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      14170571..14179798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)