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    mycla MYCL proto-oncogene, bHLH transcription factor a [ Danio rerio (zebrafish) ]

    Gene ID: 405873, updated on 28-Oct-2024

    Summary

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    Official Symbol
    myclaprovided by ZNC
    Official Full Name
    MYCL proto-oncogene, bHLH transcription factor aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2439
    See related
    Ensembl:ENSDARG00000006003 AllianceGenome:ZFIN:ZDB-GENE-040426-2439
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    L-myc; lmyc1; mycl1; mycl1a; zgc:85967
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including axial mesoderm; nervous system; pectoral fin bud; presumptive neural retina; and shield. Orthologous to human MYCL (MYCL proto-oncogene, bHLH transcription factor). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See mycla in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (35904329..35908011, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (35778497..35782179, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene potassium channel, subfamily K, member 1b Neighboring gene transforming, acidic coiled-coil containing protein 3 Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid a Neighboring gene uncharacterized LOC103912028 Neighboring gene si:ch211-67f13.7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebra fish myc family and max genes: differential expression and oncogenic activity throughout vertebrate evolution. Schreiber-Agus N, et al. Mol Cell Biol, 1993 May. PMID 8474440, Free PMC Article
    2. Using myc genes to search for stem cells in the ciliary margin of the Xenopus retina. Xue XY, et al. Dev Neurobiol, 2012 Apr. PMID 21465669
    3. Pou5f1/Oct4 promotes cell survival via direct activation of mych expression during zebrafish gastrulation. Kotkamp K, et al. PLoS One, 2014. PMID 24643012, Free PMC Article
    4. Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish. Meijer AH, et al. Dev Comp Immunol, 2008. PMID 17553562
    5. Dual regulation of lin28a by Myc is necessary during zebrafish retina regeneration. Mitra S, et al. J Cell Biol, 2019 Feb 4. PMID 30606747, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC85967

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein L-Myc-1a
    Names
    V-Myc2
    lung carcinoma myc related oncogene 1
    protein L-Myc 1
    v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog a
    v-myc myelocytomatosis viral oncogene 1, lung carcinoma derived a
    v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212937.1 → NP_998102.1  protein L-Myc-1a

      See identical proteins and their annotated locations for NP_998102.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067723
      UniProtKB/Swiss-Prot
      Q6NW51, Q9PSI9
      Related
      ENSDARP00000011307.6, ENSDART00000013961.7
      Conserved Domains (2) summary
      cd00083
      Location:292 → 346
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:17 → 269
      Myc_N; Myc amino-terminal region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      35904329..35908011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9PSI9.2 GenPept UniProtKB/Swiss-Prot:Q9PSI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.