Ighg2c immunoglobulin heavy constant gamma 2C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ighg2cprovided by MGI
Official Full Name: immunoglobulin heavy constant gamma 2Cprovided by MGI
Primary source: MGI:MGI:2686979
See related: Ensembl:ENSMUSG00000076612 IMGT/GENE-DB:IGHG2C; AllianceGenome:MGI:2686979
Gene type: other
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Igh-1b
Summary: Enables antigen binding activity. Acts upstream of or within antibacterial humoral response and humoral immune response mediated by circulating immunoglobulin. Located in extracellular space. Part of immunoglobulin complex, circulating. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 12 F1; 12 62.1 cM

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (113251009..113252552, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (113287389..113288932, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Slc15a4 is required for intact function of TLR9-expressing cells and for effective antibody isotype switching to IgG2c.
Title: Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

AI326478 (e-PCR)
- UniSTS:180487

AU044919 (e-PCR)
- UniSTS:160264

PMC312773P1 (e-PCR)
- UniSTS:272917

D12Mit41 (e-PCR), detects polymorphism
- UniSTS:141856

Igh-1 (e-PCR), detects polymorphism
- UniSTS:226082

D12Mit20 (e-PCR), detects polymorphism
- UniSTS:116787

Igh-1 (e-PCR), detects polymorphism
- UniSTS:226136

UniSTS:461920 (e-PCR)
- UniSTS:461920

Igh-6 (e-PCR), detects polymorphism
- UniSTS:461920

D12Mit263 (e-PCR), detects polymorphism
- UniSTS:126822

Igh (e-PCR), detects polymorphism
- UniSTS:143493

PMC124510P1 (e-PCR)
- UniSTS:270472

Igh-6 (e-PCR), detects polymorphism
- UniSTS:143498

Igh-8 (e-PCR), detects polymorphism
- UniSTS:143499

Igh-C (e-PCR), detects polymorphism
- UniSTS:143500

D12Mit41 (e-PCR), detects polymorphism
- UniSTS:126863

D12Mit41.1 (e-PCR), detects polymorphism
- UniSTS:126864

PMC305257P2 (e-PCR)
- UniSTS:272540

Fusip1 (e-PCR), detects polymorphism
- UniSTS:525486

PMC125735P2 (e-PCR)
- UniSTS:270513

D12Mit8 (e-PCR), detects polymorphism
- UniSTS:126899

M-04725 (e-PCR)
- UniSTS:186305

NoName (e-PCR)
- UniSTS:224213

AI324046 (e-PCR)
- UniSTS:165853

PMC150727P1 (e-PCR)
- UniSTS:271082

Other Names

immunoglobulin heavy chain 1b (serum IgG2c)

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Fc-gamma receptor I complex binding	ISO Inferred from Sequence Orthology more info
enables antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables antigen binding	IDA Inferred from Direct Assay more info	PubMed
enables immunoglobulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antibacterial humoral response	IDA Inferred from Direct Assay more info	PubMed
involved_in complement activation, classical pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immunoglobulin mediated immune response	IDA Inferred from Direct Assay more info

Component	Evidence Code	Pubs
part_of IgG immunoglobulin complex	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of immunoglobulin complex, circulating	IBA Inferred from Biological aspect of Ancestor more info
part_of immunoglobulin complex, circulating	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.