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    CD4 CD4 molecule [ Sus scrofa (pig) ]

    Gene ID: 404704, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CD4provided by VGNC
    Official Full Name
    CD4 moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:86417
    See related
    Ensembl:ENSSSCG00000000687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Broad expression in spleen (RPKM 13.1), lung (RPKM 7.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See CD4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (63892129..63918547, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 5 NC_010447.4 (66326568..66353856, complement)

    Chromosome 5 - NC_010447.5Genomic Context describing neighboring genes Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene G protein-coupled receptor 162 Neighboring gene uncharacterized LOC110260752 Neighboring gene lymphocyte activating 3 Neighboring gene uncharacterized LOC110260751 Neighboring gene parathymosin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Three functional mutation sites affect the immune response of pigs through altering the expression pattern and IgV domain of the CD4 protein. Zhang W, et al. BMC Mol Cell Biol, 2020 Dec 9. PMID 33297958, Free PMC Article
    2. Impact of a CD4 gene haplotype on the immune response in minipigs. Blanc F, et al. Immunogenetics, 2018 Apr. PMID 29052750
    3. Identification of a CD4 variant in Microminipigs not detectable with available anti-CD4 monoclonal antibodies. Matsubara T, et al. Vet Immunol Immunopathol, 2015 Dec 15. PMID 26429412
    4. Transcriptional regulation of CD4 gene expression in porcine kidney epithelial cells by virus-like double-stranded RNA and DNA methyltransferase inhibitor. Wang XS, et al. Genet Mol Res, 2014 Apr 29. PMID 24841667
    5. Novel nucleotide variants in SLA-DOB and CD4 are associated with immune traits in pregnant sows. Zhang F, et al. Gene, 2019 Jul 30. PMID 31026568

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD4 is an important host factor for Japanese encephalitis virus entry and replication in PK-15 cells.
      Title: CD4 is an important host factor for Japanese encephalitis virus entry and replication in PK-15 cells.
    2. Three functional mutation sites affect the immune response of pigs through altering the expression pattern and IgV domain of the CD4 protein.
      Title: Three functional mutation sites affect the immune response of pigs through altering the expression pattern and IgV domain of the CD4 protein.
    3. Results suggest that the SLA-DOB and CD4 genes and their genetic mutations can be considered as important candidate genes and mutations for the immunity of pregnant sows.
      Title: Novel nucleotide variants in SLA-DOB and CD4 are associated with immune traits in pregnant sows.
    4. The genetic variability of the T-cell surface glycoprotein CD4 (CD4) gene is associated with immune response-related phenotypes in MeLiM (melanoblastoma-bearing Libechov minipig) strain, which is a model for spontaneous cutaneous melanoma development and regression in minipigs.
      Title: Impact of a CD4 gene haplotype on the immune response in minipigs.
    5. The frequency and expression of a CD4 variant in microminipigs are described.
      Title: Identification of a CD4 variant in Microminipigs not detectable with available anti-CD4 monoclonal antibodies.
    6. These data help clarify the regulatory mechanism of DNA methylation of the CD4 gene in non-immune cell response to virus replication.
      Title: Transcriptional regulation of CD4 gene expression in porcine kidney epithelial cells by virus-like double-stranded RNA and DNA methyltransferase inhibitor.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in interleukin-15-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-cell surface glycoprotein CD4
    Names
    lymphocyte antigen CD4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001908.2 → NP_001001908.2  T-cell surface glycoprotein CD4 precursor

      Status: VALIDATED

      Source sequence(s)
      AEMK02000037
      UniProtKB/TrEMBL
      A0A8D0WVR8, I3L556
      Related
      ENSSSCP00000019155.3, ENSSSCT00000030772.4
      Conserved Domains (4) summary
      pfam05790
      Location:316 → 389
      C2-set; Immunoglobulin C2-set domain
      pfam12104
      Location:425 → 452
      Tcell_CD4_C; T cell CD4 receptor C terminal region
      pfam09191
      Location:210 → 315
      CD4-extracel; CD4, extracellular
      cl11960
      Location:30 → 124
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010447.5 Reference Sscrofa11.1 Primary Assembly

      Range
      63892129..63918547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021091199.1 → XP_020946858.1  T-cell surface glycoprotein CD4 isoform X2

      UniProtKB/TrEMBL
      F1SLT4, M4QL32
      Related
      ENSSSCP00000000733.3, ENSSSCT00000000749.4
      Conserved Domains (2) summary
      pfam09191
      Location:210 → 315
      CD4-extracel; CD4, extracellular
      cl11960
      Location:30 → 124
      Ig; Immunoglobulin domain

    2. XM_005652590.3 → XP_005652647.1  T-cell surface glycoprotein CD4 isoform X1

      UniProtKB/TrEMBL
      A0A8D0WVR8, I3L556
      Conserved Domains (4) summary
      pfam05790
      Location:316 → 389
      C2-set; Immunoglobulin C2-set domain
      pfam12104
      Location:425 → 452
      Tcell_CD4_C; T cell CD4 receptor C terminal region
      pfam09191
      Location:210 → 315
      CD4-extracel; CD4, extracellular
      cl11960
      Location:30 → 124
      Ig; Immunoglobulin domain

    3. XM_021091198.1 → XP_020946857.1  T-cell surface glycoprotein CD4 isoform X1

      UniProtKB/TrEMBL
      A0A8D0WVR8, I3L556
      Conserved Domains (4) summary
      pfam05790
      Location:316 → 389
      C2-set; Immunoglobulin C2-set domain
      pfam12104
      Location:425 → 452
      Tcell_CD4_C; T cell CD4 receptor C terminal region
      pfam09191
      Location:210 → 315
      CD4-extracel; CD4, extracellular
      cl11960
      Location:30 → 124
      Ig; Immunoglobulin domain

    RNA

    1. XR_002343823.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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