ERBB2 erb-b2 receptor tyrosine kinase 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ERBB2provided by VGNC
Official Full Name: erb-b2 receptor tyrosine kinase 2provided by VGNC
Primary source: VGNC:VGNC:40436
See related: Ensembl:ENSCAFG00845011735
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: HER-2; c-erbB-2; p185erbB2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	9	NC_051813.1 (23553798..23578971, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	9	NC_006591.4 (22233500..22257730, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	9	NC_049230.1 (22713484..22737693, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	9	NC_049269.1 (22327366..22351570, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	9	NC_049750.1 (22588363..22612587, complement)

Chromosome 9 - NC_051813.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of Recurrent Activating HER2 Mutations in Primary Canine Pulmonary Adenocarcinoma.
Title: Identification of Recurrent Activating HER2 Mutations in Primary Canine Pulmonary Adenocarcinoma.
Significant EGFR and HER-2 mRNA and protein expressions in in situ carcinomatous sites relative to invasive areas suggest that these molecules play a role during the early stages of tumor progression.
Title: HER-2 and EGFR mRNA Expression and Its Relationship with Versican in Malignant Matrix-Producing Tumors of the Canine Mammary Gland.
Further investigations are necessary to carefully assess the diagnostic and biological role specifically exerted by HER2 in CMTs and the use of canine mammary tumors as a model of HER2 over-expressing breast cancer.
Title: Investigation of HER2 expression in canine mammary tumors by antibody-based, transcriptomic and mass spectrometry analysis: is the dog a suitable animal model for human breast cancer?
Molecular phenotypes were determined immunohistochemically in three feline and two canine cases of mammary neoplasia, each presenting with multiple distant metastases. These tumours and their metastases often overexpressed the c-erbB-2 phenotype.
Title: Molecular phenotype of primary mammary tumours and distant metastases in female dogs and cats.
This study confirmed that in canine species, HER-2 over-expression does not identify a subgroup of tumours with a poor prognosis.
Title: HER-2 expression in canine morphologically normal, hyperplastic and neoplastic mammary tissues and its correlation with the clinical outcome.
HER-2 protein overexpression was found in canine malignant mammary tumours. Dogs with HER-2-overexpressing malignant mammary tumours tended to have a higher survival rate than those that expressed a normal level of HER-2 within 2 years of surgery.
Title: Increased survival in dogs with malignant mammary tumours overexpressing HER-2 protein and detection of a silent single nucleotide polymorphism in the canine HER-2 gene.
erbB2 plays a role in cardiomyocyte survival
Title: Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathways.
ventricular ErbB2 and ErbB4 receptors become activated during the development of pacing-induced heart failure, but downstream signaling is partly abrogated
Title: Ventricular ErbB2/ErbB4 activation and downstream signaling in pacing-induced heart failure.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: receptor tyrosine-protein kinase erbB-2

Names: proto-oncogene c-ErbB-2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

XP_038530893.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003217.3 → NP_001003217.3 receptor tyrosine-protein kinase erbB-2 precursor

Status: VALIDATED

Source sequence(s)

JAAUVH010000313

UniProtKB/TrEMBL

A0A8C0N763, A0A8C0R5Y5, A0A8I3NJW9

Related

ENSCAFP00845016814.1, ENSCAFT00845021390.1

Conserved Domains (5) summary

cd12094
Location:641 → 684

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:712 → 990

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:511 → 643

GF_recep_IV; Growth factor receptor domain IV

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051813.1 Reference ROS_Cfam_1.0

Range

23553798..23578971 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038674965.1 → XP_038530893.1 receptor tyrosine-protein kinase erbB-2 isoform X1

UniProtKB/TrEMBL

A0A8C0R5Y5

Related

ENSCAFP00845016914.1, ENSCAFT00845021520.1

Conserved Domains (5) summary

cd12094
Location:641 → 684

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:712 → 990

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:511 → 643

GF_recep_IV; Growth factor receptor domain IV