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    SLC2A4 solute carrier family 2 member 4 [ Canis lupus familiaris (dog) ]

    Gene ID: 403673, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SLC2A4provided by VGNC
    Official Full Name
    solute carrier family 2 member 4provided by VGNC
    Primary source
    VGNC:VGNC:53442
    See related
    Ensembl:ENSCAFG00845020724
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    GLUT4
    Orthologs
    human mouse all
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    Genomic context

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    See SLC2A4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (32343488..32349420)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (32376140..32382065)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (32444733..32450658)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (32308943..32314868)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (32267746..32273663)

    Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene claudin 7 Neighboring gene Y-box binding protein 2 Neighboring gene uncharacterized LOC111095872

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conditioning causes an increase in glucose transporter-4 levels in mononuclear cells in sled dogs. Schnurr TM, et al. Int J Biochem Cell Biol, 2014 Oct. PMID 25236492, Free PMC Article
    2. Intervention of rosiglitazone on myocardium Glut-4 mRNA expression during ischemia-reperfusion injury in cardio-pulmonary bypass in dogs. Liu B, et al. Mol Cell Biochem, 2013 Jan. PMID 23111893
    3. Cardiac glucose uptake and suppressed expression/translocation of myocardium glucose transport-4 in dogs undergoing ischemia-reperfusion. Liang GY, et al. Exp Biol Med (Maywood), 2008 Sep. PMID 18535164
    4. Chronic heart failure selectively induces regional heterogeneity of insulin-responsive glucose transporters. Ware B, et al. Am J Physiol Regul Integr Comp Physiol, 2011 Nov. PMID 21849635, Free PMC Article
    5. A method for the large-scale cloning of nuclear proteins and nuclear targeting sequences on a functional basis. Pichon B, et al. Anal Biochem, 2000 Sep 10. PMID 10964405

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that the state of conditioning had a significant effect on the glucose transporter-4 protein (GLUT4) expression at the surface of mononuclear cells.
      Title: Conditioning causes an increase in glucose transporter-4 levels in mononuclear cells in sled dogs.
    2. Damage of cardiac function during cardiopulomnary bypass are mostly associated with lower expression of Glut-4 mRNA.
      Title: Intervention of rosiglitazone on myocardium Glut-4 mRNA expression during ischemia-reperfusion injury in cardio-pulmonary bypass in dogs.
    3. Chronic heart failure selectively induces regional heterogeneity of insulin-responsive glucose transporters, GLUT4/12.
      Title: Chronic heart failure selectively induces regional heterogeneity of insulin-responsive glucose transporters.
    4. Suppressed translocation of GLUT-4 was also evident in dogs receiving 30-min ischemia
      Title: Cardiac glucose uptake and suppressed expression/translocation of myocardium glucose transport-4 in dogs undergoing ischemia-reperfusion.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in D-glucose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 4
    Names
    GLUT-4
    Insulin-responsive glucose transporter
    glucose transporter type 4, insulin-responsive

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159327.2 → NP_001152799.1  solute carrier family 2, facilitated glucose transporter member 4

      Status: VALIDATED

      Source sequence(s)
      JAAUVH010000371
      UniProtKB/TrEMBL
      A0A8C0K899, A0A8C0Q762, A0A8I3PA13
      Related
      ENSCAFP00845028720.1, ENSCAFT00845036689.1
      Conserved Domains (1) summary
      pfam00083
      Location:27 → 483
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051809.1 Reference ROS_Cfam_1.0

      Range
      32343488..32349420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038664061.1 → XP_038519989.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0K899
      Conserved Domains (1) summary
      cd17431
      Location:51 → 499
      MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    2. XM_038664062.1 → XP_038519990.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KB74, A0A8C0QYG1
      Conserved Domains (1) summary
      cl28910
      Location:1 → 317
      MFS; Major Facilitator Superfamily

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049265.1 Alternate UMICH_Zoey_3.1

      Range
      32308943..32314868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

      Range
      32267746..32273663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

      Range
      32444733..32450658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      32376140..32382065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XST2.1 GenPept UniProtKB/Swiss-Prot:Q9XST2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials