CCL5 C-C motif chemokine ligand 5 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: CCL5provided by VGNC
Official Full Name: C-C motif chemokine ligand 5provided by VGNC
Primary source: VGNC:VGNC:53197
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: RANTES
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	9	NC_051813.1 (38627353..38633796)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	9	NC_006591.4 (37039892..37046335)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	9	NC_049230.1 (37783127..37789578)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	9	NC_049269.1 (37410157..37416605)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	9	NC_049750.1 (37695725..37702162)

Chromosome 9 - NC_051813.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that the Leishmania braziliensis antigens plus saponin (LBSap) vaccine induced high levels of IL-12, IL-10, CCL4, CCL5 and CXCL8 expression within 48 hours.
Title: Dogs immunized with LBSap vaccine displayed high levels of IL-12 and IL-10 cytokines and CCL4, CCL5 and CXCL8 chemokines in the dermis.
Adipose tissue-derived mesenchymal stem cells expressed the mRNA of transforming growth factor beta (TGF-beta), IL-6, IL-8, CCL2, CCL5, VEGF,HGF, tissue inhibitor metalloproteinase-1/2, and cyclooxygenase-2 but not that of IL-10.
Title: Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables chemokine activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to type II interferon	IEA Inferred from Electronic Annotation more info	PubMed
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lymphocyte chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in monocyte chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T cell chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: C-C motif chemokine 5

Names: T-cell-specific protein RANTES; small-inducible cytokine A5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003010.2 → NP_001003010.1 C-C motif chemokine 5 precursor

See identical proteins and their annotated locations for NP_001003010.1

Status: PROVISIONAL

Source sequence(s)

AB098562

UniProtKB/Swiss-Prot

Q8HYS0

Conserved Domains (1) summary

smart00199
Location:31 → 88

SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)