U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    BDNF brain derived neurotrophic factor [ Canis lupus familiaris (dog) ]

    Gene ID: 403461, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    BDNF
    Gene description
    brain derived neurotrophic factor
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See BDNF in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (49335793..49386964, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (47689871..47691000, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (49083467..49084596, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (48338131..48339260, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (48489388..48490517, complement)

    Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119864901 Neighboring gene lin-7 homolog C, crumbs cell polarity complex component Neighboring gene uncharacterized LOC102154783 Neighboring gene uncharacterized LOC111091618

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Fahnestock M, et al. Neurobiol Aging, 2012 Mar. PMID 20447733, Free PMC Article
    2. Identification of learning and memory genes in canine; promoter investigation and determining the selective pressure. Seifi Moroudi R, et al. Mol Biol Rep, 2014 Dec. PMID 25192892
    3. Molecular phylogenetics and the origins of placental mammals. Murphy WJ, et al. Nature, 2001 Feb 1. PMID 11214319
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nerve growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nerve development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nerve growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of collateral sprouting IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    brain-derived neurotrophic factor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002975.1 → NP_001002975.1  brain-derived neurotrophic factor precursor

      See identical proteins and their annotated locations for NP_001002975.1

      Status: PROVISIONAL

      Source sequence(s)
      AB105074
      UniProtKB/Swiss-Prot
      Q7YRB4, Q9BFH2
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051825.1 Reference ROS_Cfam_1.0

      Range
      49335793..49386964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038429434.1 → XP_038285362.1  brain-derived neurotrophic factor isoform X1

      Conserved Domains (1) summary
      smart00140
      Location:141 → 248
      NGF; Nerve growth factor (NGF or beta-NGF)

    2. XM_038429436.1 → XP_038285364.1  brain-derived neurotrophic factor isoform X2

      UniProtKB/Swiss-Prot
      Q7YRB4, Q9BFH2
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    3. XM_038429435.1 → XP_038285363.1  brain-derived neurotrophic factor isoform X2

      UniProtKB/Swiss-Prot
      Q7YRB4, Q9BFH2
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049281.1 Alternate UMICH_Zoey_3.1

      Range
      48338131..48339260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

      Range
      48489388..48490517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

      Range
      49083467..49084596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      47689871..47691000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YRB4.1 GenPept UniProtKB/Swiss-Prot:Q7YRB4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials