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    MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) [ Canis lupus familiaris (dog) ]

    Gene ID: 403445, updated on 22-Jan-2024

    Summary

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    Gene symbol
    MMP3
    Gene description
    matrix metallopeptidase 3 (stromelysin 1, progelatinase)
    See related
    Ensembl:ENSCAFG00845000842
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

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    See MMP3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (29000797..29009079)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (28898123..28906399)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (29090249..29098533)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (29035847..29044131)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (28915267..28923546)

    Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 13 Neighboring gene matrix metallopeptidase 12 Neighboring gene matrix metallopeptidase 1 Neighboring gene stromelysin-1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of transforming growth factor-β3 and matrix metalloproteinase-3 on the pathogenesis of chronic mitral valvular disease in dogs. Obayashi K, et al. Am J Vet Res, 2011 Feb. PMID 21281193
    2. Dysregulation of renal MMP-3 and MMP-7 in canine X-linked Alport syndrome. Rao VH, et al. Pediatr Nephrol, 2005 Jun. PMID 15782307
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings suggested that increased TGF-beta3 and MMP-3 contribute to the pathogenesis of valvular degeneration associated with chronic mitral valve disease.
      Title: Effects of transforming growth factor-β3 and matrix metalloproteinase-3 on the pathogenesis of chronic mitral valvular disease in dogs.
    2. Both mRNA transcript levels and the activities of MMP-3 and MMP-7 are elevated in X-linked Alport syndrome (XLAS) kidneys from dogs.
      Title: Dysregulation of renal MMP-3 and MMP-7 in canine X-linked Alport syndrome.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stromelysin-1
    Names
    MMP-3
    SL-1
    matrix metalloproteinase-3
    NP_001002967.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002967.1 → NP_001002967.1  stromelysin-1 precursor

      See identical proteins and their annotated locations for NP_001002967.1

      Status: PROVISIONAL

      Source sequence(s)
      AY183143
      UniProtKB/Swiss-Prot
      Q6Y4Q5
      UniProtKB/TrEMBL
      A0A8C0K9E2
      Related
      ENSCAFP00845001083.1, ENSCAFT00845001397.1
      Conserved Domains (3) summary
      cd00094
      Location:288 → 478
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:108 → 264
      Peptidase_M10; Matrixin
      pfam01471
      Location:35 → 87
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051809.1 Reference ROS_Cfam_1.0

      Range
      29000797..29009079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049265.1 Alternate UMICH_Zoey_3.1

      Range
      29035847..29044131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

      Range
      28915267..28923546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

      Range
      29090249..29098533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      28898123..28906399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Y4Q5.1 GenPept UniProtKB/Swiss-Prot:Q6Y4Q5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.