HGF hepatocyte growth factor [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: HGFprovided by VGNC
Official Full Name: hepatocyte growth factorprovided by VGNC
Primary source: VGNC:VGNC:41674
See related: Ensembl:ENSCAFG00845025968
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 18

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	18	NC_051822.1 (21778181..21858827, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	18	NC_006600.4 (21005145..21082437, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	18	NC_049239.1 (21607548..21684870, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	18	NC_049278.1 (21417964..21495307, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	18	NC_049759.1 (20953619..21030809, complement)

Chromosome 18 - NC_051822.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphatase of regenerating liver sensitizes MET to functional activation by hepatocyte growth factor.
Title: Phosphatase of regenerating liver sensitizes MET to functional activation by hepatocyte growth factor.
Numb acts to suppress Rac1-GTP accumulation, and its loss leads to increased sensitivity toward extracellular signals that disrupt cell-cell adhesion to induce epithelial-mesenchymal transition (EMT) and cell dispersal
Title: Numb is a negative regulator of HGF dependent cell scattering and Rac1 activation.
as a mediator of SF- and Src-stimulated NF-kappaB activity. Finally, the Src/Rac1/MKK3/6/p38 and Src/TAK1/NF-kappaB-inducing kinase pathways exhibited cross-talk at the level of MKK3.
Title: Role of Src signal transduction pathways in scatter factor-mediated cellular protection.
Adipose tissue-derived mesenchymal stem cells expressed the mRNA of transforming growth factor beta (TGF-beta), IL-6, IL-8, CCL2, CCL5, VEGF,HGF, tissue inhibitor metalloproteinase-1/2, and cyclooxygenase-2 but not that of IL-10.
Title: Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells.
RIN2 connects Ras to Rab5 in the HGF-induced endocytosis of E-cadherin [RIN2]
Title: Involvement of the Ras-Ras-activated Rab5 guanine nucleotide exchange factor RIN2-Rab5 pathway in the hepatocyte growth factor-induced endocytosis of E-cadherin.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: hepatocyte growth factor

Names: SF; hepatopoeitin-A; hepatopoietin-A; scatter factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002964.1 → NP_001002964.1 hepatocyte growth factor precursor

See identical proteins and their annotated locations for NP_001002964.1

Status: PROVISIONAL

Source sequence(s)

AY543632

UniProtKB/Swiss-Prot

Q867B7

UniProtKB/TrEMBL

A0A8C0MXF6, A0A8I3SA43

Related

ENSCAFP00845036270.1, ENSCAFT00845046191.1

Conserved Domains (4) summary

smart00020
Location:494 → 718

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:210 → 288

KR; Kringle domain

cd00108
Location:302 → 384

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:40 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051822.1 Reference ROS_Cfam_1.0

Range

21778181..21858827 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038423360.1 → XP_038279288.1 hepatocyte growth factor isoform X2

UniProtKB/TrEMBL

A0A8C0MXF6, A0A8C0T823, A0A8I3PY68, A0A8I3SA43

Related

ENSCAFP00845036424.1, ENSCAFT00845046385.1

Conserved Domains (4) summary

smart00020
Location:481 → 705

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:210 → 288

KR; Kringle domain

cd00108
Location:302 → 384

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:40 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
XM_038423362.1 → XP_038279290.1 hepatocyte growth factor isoform X3

UniProtKB/TrEMBL

A0A8C0MUQ1, A0A8I3PSH5, A0A8P0NVH2

Related

ENSCAFP00845036128.1, ENSCAFT00845046016.1

Conserved Domains (4) summary

smart00020
Location:494 → 669

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:210 → 288

KR; Kringle domain

cd00108
Location:302 → 384

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:40 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
XM_038423359.1 → XP_038279287.1 hepatocyte growth factor isoform X1

UniProtKB/TrEMBL

A0A8C0MXF6, A0A8I3SA43

Conserved Domains (4) summary

smart00020
Location:489 → 713

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:205 → 283

KR; Kringle domain

cd00108
Location:297 → 379

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:40 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
XM_038423363.1 → XP_038279291.1 hepatocyte growth factor isoform X4

UniProtKB/TrEMBL

A0A8C0LGW6

Conserved Domains (3) summary

smart00020
Location:391 → 615

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:107 → 185

KR; Kringle domain

cd00108
Location:199 → 281

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...