U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    smc1al structural maintenance of chromosomes 1A, like [ Danio rerio (zebrafish) ]

    Gene ID: 403060, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    smc1alprovided by ZNC
    Official Full Name
    structural maintenance of chromosomes 1A, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-57
    See related
    Ensembl:ENSDARG00000058203 AllianceGenome:ZFIN:ZDB-GENE-040426-57
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    smc1a; smc1l1; zgc:76902; im:7158706
    Summary
    Predicted to enable DNA binding activity. Acts upstream of or within embryonic viscerocranium morphogenesis. Predicted to be located in chromosome. Predicted to be part of meiotic cohesin complex. Predicted to be active in nucleus. Is expressed in several structures, including cranium; digestive system; nervous system; optic cup; and otic vesicle. Used to study Cornelia de Lange syndrome. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 2; congestive heart failure; and developmental and epileptic encephalopathy 85. Orthologous to human SMC1A (structural maintenance of chromosomes 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See smc1al in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (12840100..12897576)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (13084023..13141499)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene si:dkey-96f10.1 Neighboring gene E3 SUMO-protein ligase ZBED1-like Neighboring gene uncharacterized LOC137489100 Neighboring gene si:dkey-150i13.2 Neighboring gene necdin-like 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome. Xu B, et al. Hum Mol Genet, 2015 Mar 15. PMID 25378554, Free PMC Article
    2. CyclinD1 Down-Regulation and Increased Apoptosis Are Common Features of Cohesinopathies. Fazio G, et al. J Cell Physiol, 2016 Mar. PMID 26206533
    3. Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. Mönnich M, et al. Gene Expr Patterns, 2009 Dec. PMID 19723591
    4. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cohesin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of meiotic cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    structural maintenance of chromosomes 1A, like
    Names
    SMC1 structural maintenance of chromosomes 1-like 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212810.2 → NP_997975.2  structural maintenance of chromosomes 1A, like

      See identical proteins and their annotated locations for NP_997975.2

      Status: PROVISIONAL

      Source sequence(s)
      AY648730
      UniProtKB/TrEMBL
      A0A8N7V0B7, Q6DRM9
      Related
      ENSDARP00000075459.2, ENSDART00000081016.4
      Conserved Domains (3) summary
      cd03275
      Location:4 → 148
      ABC_SMC1_euk; ATP-binding cassette domain of eukaryotic SMC1 proteins
      smart00968
      Location:513 → 628
      SMC_hinge; SMC proteins Flexible Hinge Domain
      pfam02463
      Location:3 → 1209
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      12840100..12897576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous